肠粘康对大鼠实验性肠粘连的预防作用

手术损伤回肠末段造成大鼠实验性肠粘连,以等级记分法评价肠粘连程度。手术对照组全部出现较严重的肠粘连。肠粘康浸膏20g/kg 灌胃,每天1或2次,连续5天,显著减轻肠粘连的严重程度,并有部分大鼠完全不出现肠粘连,与手术对照组相比有显著差异(P<0.01和 P<0.05)。结果表明肠粘康具有较好的抗肠粘连作用。

Preventive Effect of Changzhankang in Experimental Intestinal Adhesions of Rats

Intestinal adhesions were induced in rats by stabbing the terminal part of the ileum.Adhesion prevention by ibuprofen and Changzhankang(CZK),which was composed by traditional Chinese medicines,was evaluated with a grading system.All of the 13 rats in the non-treated group created severe-adhesions.The severity was significantly modified by orally administered CZK of 20 g/kg (in crude drugs)once or twice daily for five days (P<0.01 and P<0.05 compared with the non-treated).Intramuscular injection of ibuprofen (35 mg/kg,3 times daily)also alleviated the severity of adhesions.There was no significant difference between the ibuprofen-treated and CZK-treated groups though some of the rats were virtually free from adhesion formation in the latter.It is plausible to expect CZK to become a promising drug used in treating intestinal adhesions, for the natural drug has greater security and less side effects than synthesized drugs.