| β-受体阻滞剂的分析研究 |
| |
| 引用本文： | 段宏瑾,方洪钜,周同惠,陈超.β-受体阻滞剂的分析研究[J].药学学报,1991,26(5):351-357. |
| |
| 作者姓名： | 段宏瑾 方洪钜 周同惠 陈超 |
| |
| 作者单位： | 中国医学科学院药物研究所，中国医学科学院药物研究所，中国医学科学院药物研究所，国家体委体育运动医学研究所 北京 100050，北京 100050，北京 100050，北京 100061 |
| |
| 摘 要： | 本文叙述了用高效毛细管气相色谱/氮磷检测器及气相色谱/质量选择检测器对13种β-受体阻滞剂的分析研究。样品用不同衍生化方法作了比较,初步结果表明:衍生化效果TFAA与MBTEA无很大差异;而MSTFA比上述两者效果均佳。本文的研究为β-受体阻滞剂的体液气相色谱研究提供了可行的方法。
|
| 关 键 词： | β-受体阻滞剂 高分辨气相色谱法 气相色谱/质量选择检测器 |
| 收稿时间： | 1990-01-31 |
STUDIES ON THE ANALYSIS OF BETA-BLOCKING AGENTS |
| |
| HJ Duan,HJ Fang,TH Zhou and C Chen.STUDIES ON THE ANALYSIS OF BETA-BLOCKING AGENTS[J].Acta Pharmaceutica Sinica,1991,26(5):351-357. |
| |
| Authors: | HJ Duan HJ Fang TH Zhou and C Chen |
| |
| Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing. |
| |
| Abstract: | A method for the separation and identification of 13 beta-blockers using GC/MS and GC/NPD are described. The TFA and TMS derivatives were prepared by adding TFAA, MSTFA and MBTFA to the standard drugs. The mixture was heated at 65 degrees C for 20 min and chromatographed on FS capillary columns (HP-5). Preliminary results show that the derivatization with MSTFA is better than that with TFAA or MBTFA. There is not much difference between TFAA and MBTFA derivatization. The method is reliable, rapid and simple and may be used to screen these drugs and further applied to the analysis of biological fluids such as plasma and urine. |
| |
| Keywords: | Beta-blockers GC/MSD GC/NPD |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
| 点击此处可从《药学学报》下载免费的PDF全文 |
