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Muscle spindles in rheumatoid arthritis
Authors:Eva Magyar  A. Talerman  W. C. de Bruijn  Judith Mohácsy  H. W. Wouters
Affiliation:(1) Department of Pathology, Postgraduate Medical School, Budapest, Hungary;(2) Department of Pathology and Orthopaedic Surgery, Dr. Daniel den Hoed Kliniek, Rotterdam, Holland;(3) Department of Pathology, Erasmus University, Rotterdam, Holland;(4) 2nd Department of Pathology, Semmelweis Medical School, Budapest, Hungary
Abstract:Summary Ultrastructural features of muscle spindles were studied in biopsy material from 100 patients suffering from classical rheumatoid arthritis. Thickening of the outer capsule, increased amount of extracellular ground substance within the inner capsule, and marked thickening of the basement membrane of capillary blood vessels supplying the muscle spindles were observed. Chronic inflammatory cells and macrophages were present within the spindles. Changes affecting the intrafusal muscle fibres were also seen. They were manifest as atrophy and degeneration of the intrafusal muscle fibres, absence of the specialised junctional complexes, and of the intercellular bridges, microladders and satellite cells. It is suggested that the changes affecting the intrafusal muscle fibres are probably secondary. Damage to the myelinated nerves was present, while the sensory and motor nerve endings were well preserved.Temporary Research Fellow the Rotterdam Centre for Rheumatic DiseasePresent address: Division of Pathology, Department of Obstetrics and Gynaecology, University of Chicago, Chicago, Illinois 60637, USA
Keywords:Rheumatoid arthritis  Muscle spindles  Neuromuscular spindles  Ultrastructure
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