曲普瑞林和米非司酮治疗子宫肌瘤的效果对比观察

目的：探讨曲普瑞林和米非司酮治疗子宫肌瘤的临床效果。方法选取76例子宫肌瘤患者作为研究对象,随机分为对照组37例和治疗组39例,对照组采用曲普瑞林治疗,治疗组采用米非司酮治疗。通过B超检测用药前后子宫及子宫肌瘤的三维径线并计算体积,测定患者的促卵泡激素（FSH）、雌二醇（E2）和血红蛋白水平,观察服药后的不良反应。结果两组治疗后的血红蛋白水平显著高于治疗前,FSH和E2水平显著低于治疗前,差异有统计学意义（P＜0.05）,两组治疗后的子宫体积和肌瘤体积显著小于治疗前,差异有统计学意义（P＜0.05）,治疗组治疗后的FSH和E2水平显著低于对照组,差异有统计学意义（P＜0.05）。结论米非司酮能有效减小子宫肌瘤体积,降低雌、孕激素水平,疗效良好,不良反应较轻,可为临床用药提供参考。

Effect comparison observation of triptorelin and mifepristone in the treatment of uterine fibroid

Objective To explore the clinical effect of triptorelin and mifepristone in the treatment of uterine fibroid. Methods 76 cases with uterine fibroid were randomly divided into control group（37 cases） and treatment group（39 cas-es）.The control group was treated with triptorelin,the treatment group was treated with mifepristone.The 3D lines in uterus and uterine fibroid before and after treatment were measured and calculated by medical ultrasound,the level of follicle stimulating hormone （FSH）,estradiol （E2）,hemoglobin and drug adverse reactions were observated. Results The levels of hemoglobin after treatment in two groups was lower than that before treatment,the levels of FSH,E2 after treat-ment in two groups was higher than that after treatment,with statistical difference （P〈0.05）.Compared with before treat-ment,and the volume of uterine and fibroid after treatment was smaller than that before treatment,with statistical differ-ence （P〈0.05）,the levels of FSH,E2 after treatment in treatment group was higher than that in control group,with statisti-cal difference（P〈0.05）. Conclusion Mifepristone can effectively decrease the volume of uterine fibroid,reduce the levels of estrogen and progestogen,and has good curative effect,less adverse reactions,which can provide reference for the clin-ical use of drugs.