辛伐他汀对老年急性心肌梗死患者白细胞介素-6的影响

目的探讨老年人急性心肌梗死(AMI)患者外周循环白细胞介素-6(IL-6)和白细胞(WBC)数的变化及辛伐他汀对IL-6和WBC数的影响.方法测定39例老年AMI患者(AMI组)和20例老年陈旧性心肌梗死(OMI)患者(OMI组)血清IL-6浓度和外周血WBC数.39例AMI患者入院后随机分为辛伐他汀组和对照组,治疗前及治疗后1周和6周测定血清IL-6浓度及外周血WBC数.结果 AMI组血清IL-6水平及外周血WBC数均明显高于OMI组(P＜0.001);血清IL-6与WBC及肌酸激酶同工酶(CK-MB)呈显著正相关(P＜0.05);治疗后1周和6周,辛伐他汀组和对照组IL-6水平及WBC数均显著下降(P＜0.01及P＜0.001),且治疗后6周辛伐他汀组IL-6水平及WBC数明显低于对照组(P＜0.05).结论 AMI患者外周循环IL-6浓度及WBC数明显升高,且IL-6与WBC及CK-MB呈正相关;辛伐他汀具有调节外周循环IL-6水平及WBC数的作用.

Effect of simvastatin on interleukin-6 in patients with acute myocardial infarction

Objective: To investigate the changes of interleukin-6 (IL-6) and white blood cell(WBC) count in patients with acute myocardial infarction (AMI) and the effects of simvastatin. Methods: Serum IL-6 was measured with the method of ELISA in 39 AMI patients and 20 old myocardial infarction (OMI) patients. The 39 AMI patients were randomized into simvastatin group (n =20) and control group (n =19). Serum IL-6 level and WBC count were examined before and after I week and 6 weeks of treatment. Results: The serum level of IL-6 and WBC count in the AMI group were significantly higher than those in the OMI group (P<0.001). The correlation analysis showed that serum IL-6 level had positive correlation with WBC count (P<0.05) and the MB fraction of creatine kinase (CK-MB) Level (P<0.05) before treatment. serum IL-6 and WBC count were significantly decreased after 1 week and 6 weeks of treatment (P<0.01, P<0.001) in simvastatin group and control group. The serum IL-6 level and WBC count in the simvastatin group were significantly lower than those in control group after 6 weeks' treatment (P<0.05). Conclusions: In the AMI patients, the level of IL-6 and WBC count are significantly increased. The serum IL-6 level is significantly positively correlated with WBC count and CK-MB level. Simvastatin can modulate the level of serum IL-6 and WBC count in AMI patients.