| 中药知母有效成分研究 |
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| 引用本文： | 董俊兴,韩公羽. 中药知母有效成分研究[J]. 药学学报, 1992, 27(1): 26-32 |
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| 作者姓名： | 董俊兴 韩公羽 |
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| 作者单位： | 第二军医大学药学院 上海(董俊兴)，第二军医大学药学院 200433(韩公羽) |
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| 摘 要： | 自内蒙古赤峰地区产知母(Anemarrhena asphodeloides Bumge)根茎的乙醇提取物中分得单体化合物知母皂甙A1(Ⅰ),A2(Ⅱ)和B(Ⅲ)。经化学和波谱方法(UV,IR,EI-MS,FAB-MS,1H-NMR和13C-NMR),以鉴定其化学结构分别为萨尔萨皂甙元-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(Ⅰ)、吗尔考皂甙元-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(Ⅱ)和26-O-β-D-吡喃葡萄糖基呋甾-20(22)-烯-3β-2,6-二醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(Ⅲ)。Ⅲ为一新的甾体皂甙,且其甙元也是首次在天然界中发现。经初步药理实验显示,Ⅲ具有抑制PAF诱导的兔血小板聚集的作用。
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| 关 键 词： | 知母 知母皂甙 甾体皂甙 血小板聚集 |
| 收稿时间： | 1990-09-03 |
STUDIES ON THE ACTIVE CONSTITUENTES OF ANEMARRHENA ASPHODELOIDES BUNGE |
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| JX Dong,GY Han. STUDIES ON THE ACTIVE CONSTITUENTES OF ANEMARRHENA ASPHODELOIDES BUNGE[J]. Acta pharmaceutica Sinica, 1992, 27(1): 26-32 |
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| Authors: | JX Dong GY Han |
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| Affiliation: | College of Pharmacy, Second Military Medical Universlity, Shanghai. |
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| Abstract: | From the ethanol extract of the Anemarrhena asphodeloides Buge (Liliaceae), a new steroidal suponin anemarsaponin B and two known saponins anemarsaponin A1 and A2 were isolated. On the basis of chemical evidences and spectral analysis (UV, IR, EI-MS, FAB-MS, 1H-NMR and 13C-NMR), the structure of anemarsaponin B was elucidated as 26-O-beta-D-glucopyranosylfurost-20(22)-ene-3 beta,26-diol-3-O-beta-D- glucopyranosyl(1----2)-beta-D-galactopyranoside. Preliminary pharmacological tests showed that anemarsaponin B could inhibit PAF-induced rabbit platelet aggregation in vitro. |
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| Keywords: | Anemarrhena asphodeloides Anemarsaponin Steroidal saponin Platelet aggregation |
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