Effect of gammaglobulin on pneumococcal otitis media in the rat.

Previously it has been found possible to induce pneumococcal AOM that closely resembles human infections, in the rat. In this study, the rat model has been used to study the possibilities to affect the infection by administration of gammaglobulin. The gammaglobulin was administered either systemically by intravenous injection of 0.2 g/kg bodyweight in 15 rats, or topically when 8 mg was instilled into the middle ear cavity of 18 rats. Although intravenous administration in this model failed to provide protection from AOM, topical administration simultaneously with the bacterial challenge was successful.