手足浸泡方治疗手足综合征临床研究

目的:观察手足浸泡方治疗化疗后手足综合征(hand-foot syndrome,HFS)的临床疗效。方法:将79例HFS患者随机分为对照组A 30例、对照组B 19例和治疗组30例。各组均给予化疗,化疗开始时即予下述治疗:治疗组予手足浸泡方,对照组A给予质量分数0.3%聚维酮碘,对照组B口服维生素B6。观察各组患者的临床疗效、总化疗时间及治疗前后神经电生理变化情况。结果:对照组A有效率为70.0%,对照组B有效率为63.2%,治疗组有效率为86.7%,三组比较,差异具有统计学意义(P0.05)。治疗组、对照组A、对照组B总化疗时间分别为(4.24±1.02)个月、(6.20±1.35)个月、(6.51±1.41)个月,治疗组与其他两组比较,差异均有统计学意义(P0.05)。各组患者治疗前后神经生理变化比较,差异均无统计学意义(P0.05)。结论:手足浸泡方能显著减轻化疗后手足综合征的症状,提高患者对化疗的耐受性,改善患者的生活质量。

The Clinical Research into Hand-Foot Syndrome Treated with Hand-Foot Soaking Decoction

Objective:To observe the clinical curative effect of Hand-Foot Soaking Decoction on hand-foot syndrome (HFS).Methods:Seventy-nine patients were randomly divided into the control group A with 30 cases,the control group B with 19 cases and the treatment group with 30 cases.Each group was given chemotherapy.Since the beginning of chemotherapy,the ones in the treatment group were treated with Hand-Foot Soaking Decoction;The ones in the control group A were treated with povidone iodine with 0.3％ of mass fraction;The ones in the control group B were treated with vitamin B6 for oral administration.Then the three groups' clinical curative effects,total chemotherapy time,and the changes of electrophysiology before and after treatment were observed.Results:The effective rate of the control group A was 70％,while that of the control group B 63.2％,and that of the treatment group was 86.7％;The differences between the three groups were statistically significant((P＜0.05).The total chemotherapy time of the treatment group,the control group A and the control group B was (4.24 ± 1.02) months,(6.20 ± 1.35) months and(6.51 ± 1.41) months respectively.The differences between the treatment group and the other two groups were statistically significant (P ＜ 0.05).There was no significant difference in neurophysiological changes before and after the treatment in each group (P ＞ 0.05).Conclusion:Hand-Foot Soaking Decoction can significantly reduce the symptoms of hand foot syndrome after chemotherapy,improve the patient's tolerance to chemotherapy and improve their quality of life.