健脾益肾颗粒联合替米沙坦对代谢综合征患者肝肾功能及血管内皮功能的影响

目的:观察健脾益肾颗粒联合替米沙坦对代谢综合征(metabolism syndrome,MS)患者肝肾功能及血管内皮功能的影响。方法:选取2012年8月—2015年1月在本院接受治疗的MS患者158例,随机分成对照组和观察组,每组79例。对照组给予替米沙坦治疗,观察组在对照组治疗的基础上加用健脾益肾颗粒治疗。观察治疗前后两组患者肝肾功能、血管内皮功能的变化情况。结果:治疗后,两组ALT、AST、BUN、Cr水平比较,差异无统计学意义(P0.05);治疗后,观察组NO、SOD、FMD、ET-1水平均优于对照组,差异具有统计学意义(P0.05)。结论:健脾益肾颗粒联合替米沙坦可显著改善MS患者血管内皮功能,且不会对肝肾功能造成影响。

Influence of Spleen-Strengthening and Kidney-Benefiting Granules Combined with Telmisartan on the Liver and Kidney Function and Vascular Endothelial Function of Patients with Metabolism Syndrome

Objective:To observe the influence of Spleen-Strengthening and Kidney-Benefiting Granules combined with Telmisartan on the liver and kidney funetion and vascular endothelial fumction of patients with metabolism syndrome (MS).Methods:Totally 158 MS patients treated in this hospital between August 2012 and January 2015 were randomized into control group and observation group,79 cases in each group.Control group were given Telmisartan for the treatment while observation group were added with Spleen-Strengthening and Kidney-Benefiting Granules.The changes of liver and kidney function and vascular endothelial function were observed after treatment.Results:After treatment,the difference of the levels of ALT,AST,BUN and Cr had no statistical significance (P ＞ 0.05).The levels of NO,SOD,FMD and ET-1 in observation group were superior to those in control group;the difference had statistical significance (P ＜ 0.05).Conclusion:Spleen-Strengthening and Kidney-Benefiting Granules combined with Telmisartan can significantly improve the vascular endothelial function without affect the liver and kidney function in patients with MS.