消瘤饮Ⅰ号方联合化疗治疗中晚期非小细胞肺癌43例

目的:观察消瘤饮Ⅰ号方联合化疗治疗中晚期非小细胞肺癌患者的临床效果,探讨其对患者血清细胞角蛋白19可溶性片段(Cell keratin19,CYFRA19)、血管内皮生长因子(vascular endothelial growth factor,VEGF)、糖类抗原199(carbohydrate antigen,CA199)、鳞状上皮细胞癌抗原(Squamous cell carcinoma antigen,SCC-Ag)等水平的影响.方法:将86例本院收治的中晚期非小细胞肺癌患者随机分为对照组和观察组各43例.对照组给予化疗,观察组在化疗基础上加用消瘤饮Ⅰ号方.比较两组患者临床疗效,评价两组患者治疗后的生活质量,监测治疗前后血清CYFRA21-1、VEGF、CA199、SCC-Ag水平变化.结果:观察组有效率为65.1％,对照组有效率为34.9％,两组有效率比较差异有统计学意义(P＜0.05);观察组治疗后生活质量相关的生理、活动功能、情感、社会的FACT-L评分与对照组比较有统计学意义(P＜0.05);两组患者治疗后血清CYFRA21-1、VEGF、CA199、SCC-Ag与治疗前比较有统计学意义(P＜0.05),观察组下降程度与对照组比较有统计学意义(P＜0.05).结论:消瘤饮Ⅰ号方联合化疗能显著提高中晚期非小细胞肺癌患者的近期疗效,提高患者FACT-L评分,其机制与下调血清CYFRA21-1、VEGF、CA199、SCC-Ag等因子表达而提高免疫功能、抑制癌细胞生长有一定相关性.

Forty-Three Cases of Advanced Non-small Cell Lung Cancer Treated with No.1 Tumor-Removing Decoction in Combination with Chemotherapy

Objective:To observe the clinical curative effect of No.1 Tumor-Removing Decoction in combination with chemotherapy on patients with advanced non-small cell lung cancer(NSCLC),to explore their influence on the patients' levels of cell keratin 19 (CYFRA19),vascular endothelial growth factor (VEGF),carbohydrate antigen (CA199),squamous cell carcinoma antigen (SCC-Ag).Methods:Eighty-six patients who were treated in our hospital were chosen as the reseach subjects,and randomly divided into the control group and the observation group,with 43 cases in each group.The ones in the control group were treated with chemotherapy,while the ones in the observation group were added No.1 Tumor-Removing Decoction based on the treatment of the control group.The clinical efficacies of the two groups were compared and the quality of life in the two groups was evaluated.The changes of serum CYFRA21-1,VEGF,CA199 and SCC-Ag levels were monitored before and after the treatment.Results:The effective rate of the observation group was 65.1％,while that of the control group was 34.9％;And the difference between them had statistical significance (P ＜0.05).After the treatment,the differences in physiological function,emotional and social FACT-L score related to quality of life between the two groups were statistically significant (P ＜ 0.05).Compared with before the treatment,the two groups' serum CYFRA21-1,VEGF,CA199 and SCC-Ag were statistically significant (P ＜ 0.05).The difference in decreased degree between the two groups was statistically significant (P ＜ 0.05).Conclusion:No.1 Tumor-Removing Decoction in combination with chemotherapy can significantly improve the curative effect in advanced non small cell lung cancer patients,improve the patients' FACT-L score.Their mechanism is related to improving immune function and inhibiting cancer cell growth by decreasing serum CYFRA21-1,VEGF and CA199 decreased,SCC-Ag expression.