加味下瘀血汤治疗慢性乙型病毒性肝炎临床观察

目的:观察加味下瘀血汤治疗慢性乙型病毒性肝炎患者的临床疗效。方法:选取2012年9月—2015年9月本院肝炎门诊和病房诊治的CHB患者110例,随机分为对照组和治疗组,每组55例。两组患者均给予恩替卡韦口服治疗,治疗组另给予加味下瘀血汤治疗。结果:治疗组显效9例,有效34例,无效12例,总有效率78.18%;对照组显效11例,有效35例,无效9例,总有效率83.64%。经统计分析,两组疗效比较,无明显统计学差异(P0.05);治疗后,治疗组患者乏力、胁痛胁胀、纳差中医证候评分明显下降,且优于对照组(P0.05);治疗组治疗后HA、LN、PCⅢ、AKP水平优于对照组(P0.05);治疗组治疗后患者血清CD4~+、CD8~+、CD4~+/CD8~+变化情况优于对照组(P0.05);治疗组治疗后血清IL-2、IL-10、IL-6水平优于对照组(P0.05)。结论:加味下瘀血汤治疗慢性乙型病毒性肝炎疗效显著,可有效改善患者乏力、胁痛胁胀、纳差等中医证候,改善肝纤维化,调节细胞免疫。

Clinical Observation of the Effects of Supplemented Discharging Blood Stasis Decoction on Chronic Viral Hepatitis B

Objective:To observe the clinical effects of Supplemented Discharging Blood Stasis Decoction on chronic viral hepatitis B.Methods:Totally 110 patients with CHB treated in this hospital between September 2012 and September 2015 were randomized into control group and treatment group,55 cases in each group.Both groups were given oral administration of Entecavir while treatment group were added with Supplemented Discharging Blood Stasis Decoction.Results:In treatment group,9 cases had excellent effects,34 cases with effects and 12 crases without effect;the total effective rate was 78.18％;in control group,11 cases had excellent effects,35 cases with effects and 9 cases without effect;the total effective rate was 83.64％.The difference of the effects between two groups had no statistical significance (P ＞ 0.05).After treatment,the TCM symptom scores of fatigue,hypochondriac pain and distension and poor appetite in treatment group declined significantly,superior to those in control group (P ＜0.05).The levels of HA,LN,PC Ⅲ and AKP in treatment group were superior to those in control group (P ＜ 0.05).The changes of the levels of CD4 +,CD8 + and CD4 +/CD8 + and the levels of IL-2,IL-10 and IL-6 in the serum in treatment group were superior to those in control group (P ＜ 0.05).Conelusion:Supplemented Discharging Blood Stasis Decoc tion has significant therapeutic effects on chronic viral hepatitis B,which can effectively improve the TCM symptoms of fatigue,hypochondriac pain and distension,poor appetite and the liver fibrosis and regulate cellular immunity.