银翘散加减治疗小儿多发性抽动症的临床研究

目的：观察银翘散加减对小儿多发性抽动症的疗效，并分析其作用机制。方法选取2013年6月至2015年7月我院收治的小儿多发性抽动症患儿64例为研究对象，采用随机数字表法分为观察组和对照组各32例，对照组给予西药氟哌啶醇治疗，观察组在此基础上加用银翘散，均治疗3个月。比较两组治疗有效率，应用美国耶路综合抽动严重程度量表（YGTSS）分析其抽动程度，采用原子吸收光谱仪分析两组血清微量元素铁（Fe）、锌（Zn）水平，同时以酶联免疫法（ELISA）检测血清免疫球蛋白（IgE）水平，并记录不良反应发生率。结果观察组治疗有效率93.7％明显高于对照组75.0％（P<0.05）；治疗后观察组运动性抽动评分、发声性抽动评分、YGTSS评分总分、IgE水平明显低于对照组（P<0.05），观察组血清Fe、Zn水平较对照组高（P<0.05）；两组不良反应发生率比较无显著差异（P>0.05）。结论银翘散可能通过调节血清IgE及微量元素Fe、Zn水平有效治疗小儿多发性抽动症，且安全性高，值得在临床推广应用。

Clinical Study of Modified Yinqiao Powder in the Treatment of Tourette's Syndrome

Objective To observe the effects of modified Yinqiao powder in the treatment of Tourette's syndrome, and analyze its mechanism. Methods From June 2013 to July 2015, 64 cases with Tourette's syndrome in our hospital were se-lected as study subjects and were randomly divided into the observation group and the control group, 32 cases in each group. The control group was treated with haloperidol while the observation group was additionally treated with Yinqiao powder, and both groups were treated for 3 months. The effective rate of treatment was compared between the two groups, and the degree of tic was evaluated by American Yale Global Tic Severity Scale (YGTSS). The levels of serum trace elements ferrum (Fe) and zinc (Zn)] were detected by atomic absorption spectrometry, and the serum immunoglobulin (IgE) was detected by enzyme-linked immunosorbent assay (ELISA). The adverse reactions were recorded. Results The effective rate of treatment in the ob-servation group (93.7%) was higher than that in the control group (75.0%) (P<0.05). After treatment, the scores of motor tic and occurrence tic, YGTSS score and IgE level in the observation group were significantly lower while the levels of Fe and Zn were significantly higher than those in the control group (all P<0.05). There was no significant difference in the incidence rate of adverse reactions between two groups (P>0.05). Conclusion Yinqiao powder could treat Tourette's syndrome by regulat-ing levels of serum IgE and trace elements Fe and Zn, with high safety. It is worthy of the clinical popularization.