参松养心胶囊对急性心肌梗死患者室性心律失常及心电图QT离散度的影响

目的:观察参松养心胶囊对急性心肌梗死(Acute myocardial infarction,AMI)患者室性心律失常及心电图QT离散度(QT Dispersiond,QTd)的影响。方法:将62例急性心肌梗死患者随机分为观察组和对照组,每组各31例。在常规溶栓治疗的基础上,对照组给予美托洛尔治疗,观察组在对照组的基础上给予参松养心胶囊治疗,观察两组患者的临床疗效,比较两组患者治疗后24 h与治疗后7 d室性心律失常发生情况及治疗前后心电图QTd变化。结果:观察组有效率为87.10%,对照组有效率为64.52%,两组患者临床疗效比较,差异具有统计学意义(P0.05)。观察组治疗后24 h和7 d室性心律失常发生率均低于对照组,差异具有统计学意义(P0.05)。两组用药后QTd间期均有下降,组内每两个时刻相比较,差异均有统计学意义(P0.05)。观察组治疗24 h及7 d后心电图QTd间期明显优于对照组,差异均有统计学意义(P0.05)。结论:参松养心胶囊可明显减少AMI患者室性心律失常的发生,缩短QTd间期,疗效显著且安全性高。

The Influence of Shensong Yangxin Capsules on Ventricular Arrhythmia and Electrocardiogram QT Dispersion of Patients with Acute Myocardial Infarction

Objective:To observe the influence of Shensong Yangxin Capsules (SSYXC) on ventricular arrhythmia and electrocardiogram QT dispersion of patients with acute myocardial infarction.Methods:Sixty-two patients with acute myocardial infarction were randomly divided into observation group and control group,with 31 cases in each group.Based on the conventional thrombolytic therapy,the control group was given metoprolol treatment,the observation group was added SSYXC based on the treatment of the control group.Then the clinical efficacies of the two groups were observed,their ventricular arrhythmia 24 hours and 7 days after the treatment respectively,and ECG QTd changes before and after the treatment were compared.Results:The effective rate of the observation group was 87.10％,while that of the control group was 64.52％,and the difference in clinical efficacy of the two groups was statistically significant (P ＜ 0.05).The incidence of ventricular arrhythmia in the obseryation group after 24 hours and 7 days respectively after the treatment was lower than that in the control group,the difference was statistically significant (P ＜0.05).After taking drugs,the QTd interval in two groups decreased,and all the differences between each two-time point were significant (P ＜ 0.05).After 24 hours' and 7 days' treatment respectively,the observation group's ECG QTd interval was significantly better than that of the control group,and the difference was statistically significant (P ＜ 0.05).Conclusion:SSYXC can significantly reduce the incidence of ventricular arrhythmia in patients with AMI,shorten the QTd interval,the efficacy is significant and safe.