| 糖尿病肾病动物模型研究进展 |
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| 引用本文： | 张浩军,赵静波,李平.糖尿病肾病动物模型研究进展[J].中国药理学通报,2008,24(7):845-848. |
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| 作者姓名： | 张浩军 赵静波 李平 |
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| 作者单位： | 1. 中日友好医院临床医学研究所,北京,100029
2. Center for Visceral Biomechanics and Pain Aalborg Hospital Science & Innovation Center Sdr.Skovvej 15,DK-9000 Aalborg Denmark |
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| 基金项目： | 国家重点基础研究发展计划(973计划)
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科技部国际科技合作计划
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首都医学发展科研项目 |
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| 摘 要： | 糖尿病肾病是危害人类健康的重大疾病,选择合适的动物模型揭示该病的发病机制及其防治至关重要。该文对国内外相关动物模型的研究现状进行分析,指出诱发性、自发性及转基因三类动物模型的优势与不足,并对各模型致病机制、疾病表现、肾脏病理改变及应用等进行了比较,目的在于完善糖尿病肾病的相关模型,为今后防治糖尿病肾病的药物研究提供良好的实验平台。
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| 关 键 词： | 糖尿病肾病 动物模型 |
Progress in the study on animal model of diabetic nephropathy |
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| ZHANG Hao-jun,ZHAO Jing-bo,LI Ping.Progress in the study on animal model of diabetic nephropathy[J].Chinese Pharmacological Bulletin,2008,24(7):845-848. |
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| Authors: | ZHANG Hao-jun ZHAO Jing-bo LI Ping |
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| Abstract: | Diabetic nephropathy(DN) greatly affects human health.It is critical to select suitable animal model for the research on the disease.In the paper,the status quo of domestic and abroad research related to animal model is analyzed,pointing out the advantage and disadvantage of drug-induced,spontaneous and transgenic animal model.Comparision is made between different etiopathogenesis,symptoms and renal pathological changes in each mode.It is to consummate DN related models and provide laboratory flat for pharmaceutic research on DN. |
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| Keywords: | diabetic mephropathy animal model |
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