| 胆囊收缩素对实验性神经细胞老化过程中微突起影响的超微结构研究 |
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| 引用本文： | 孙晓江,励斌,蔡琰. 胆囊收缩素对实验性神经细胞老化过程中微突起影响的超微结构研究[J]. 中国老年学杂志, 2002, 22(6): 497-499 |
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| 作者姓名： | 孙晓江 励斌 蔡琰 |
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| 作者单位： | 1. 上海市第六人民医院神经科学实验室,上海,200233
2. 上海第二医科大学附属仁济医院 |
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| 基金项目： | 上海市自然科学基金资助项目 (98ZB1 4 0 4 0 ) |
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| 摘 要： | 目的 探讨胆囊收缩素 (CCK8)对实验性神经细胞老化过程中细胞微突起超微结构的影响。方法 采用 NBA2 细胞无血清培养建立神经细胞老化实验模型。以扫描电子显微镜观察的细胞表面结节状物的大小以及微突起数目作为细胞老化指标 ,观察 CCK8对细胞老化过程的影响。结果 1使细胞表面结节状物变小。 2增加细胞突起终末的微突起数量。结论 CCK8可以延缓实验性神经细胞的老化进程值得进一步研究。
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| 关 键 词： | CCK8 实验性神经细胞老化 微突起 |
| 文章编号： | 1005-9202(2002)06-0497-03 |
| 修稿时间： | 2002-02-16 |
The ultrastructural research of the effects of cholecystokinin on experimental neuron during aging |
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| SUN Xiao jiang,Li Bin,CAI Yan Neuroscience Research Laboratory,Shanghai Sixth People's Hospital,Shanghai. The ultrastructural research of the effects of cholecystokinin on experimental neuron during aging[J]. Chinese Journal of Gerontology, 2002, 22(6): 497-499 |
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| Authors: | SUN Xiao jiang Li Bin CAI Yan Neuroscience Research Laboratory Shanghai Sixth People's Hospital Shanghai |
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| Affiliation: | SUN Xiao jiang,Li Bin,CAI Yan Neuroscience Research Laboratory,Shanghai Sixth People's Hospital,Shanghai 200233 |
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| Abstract: | Objective To observe the effects of Cholecystokinin(CCK 8) on dendritic spines during experimental neuronal aging.Methods Serum free culture of mouse neurobastoma A2 cells was used as the experimental model for the study of neuronal aging, with the following as indices of cellular aging: (1) shortening and transformation into tuberous granules of the microvilli on cell surfaces (scanning EM) and (2) diminution an final disappearance of terminal dendritic spines (scanning EM).Results After additiion of CCK 8 into the culture medium, the following results were obtained: (1) decrease of transformation into tuberous granules of the microvilli,and (2)increase of terminal dendritic spines. Conclusions CCK 8 had the effect in the direction of delaying experimental neuron cell aging. The effects of CCKs on neuronal aging merit further investigation. |
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| Keywords: | CCK 8 Experimental neuron aging Dendritic spine |
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