Neoadjuvant chemotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer |
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Authors: | Elliot Newman M.D. Stuart G. Marcus M.D. Milan Potmesil M.D. Sanjeev Sewak M.D. Herman Yee M.D. Joan Sorich R.N. Mary Hayek B.Sc. Franco Muggia M.D. Howard Hochster M.D. |
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Affiliation: | (1) Department of Surgery, New York University School of Medicine, and Kaplan Comprehensive Cancer Center, New York, New York;(2) Department of Medicine, New York University School of Medicine, and Kaplan Comprehensive Cancer Center, New York, New York;(3) Department of Pathology, New York University School of Medicine, and Kaplan Comprehensive Cancer Center, New York, New York;(4) NYU Medical Center, 530 First Ave., Suite 6C, 10016 New York, NY |
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Abstract: | We examined the role of neoadjuvant therapy in downstaging locally advanced gastric cancer. Preoperative staging was performed with a combination of CT scans, endoscopic ultrasonography and/or laparoscopy, and laparoscopic ultrasonography. Patients with T ⋝3 tumors and/or node-positive disease by preoperative clinical staging were eligible for entry. Neoadjuvant therapy consisted of two cycles of CPT-11 (75 mg/m2) with cisplatin (25 mg/m2) weekly four times every 6 weeks. This was followed by resection with D2 lymph node dissection and two cycles of intraperitoneal chemotherapy with floxuridine and cisplatin. Twenty-two patients were entered into the study (4 with T3N0 disease and 18 with T3N1 disease). Induction chemotherapy was well tolerated with major toxicities being neutropenia and diarrhea. A median of 78%/75% of the planned dosage of CPT-11/cisplatin was delivered. Two patients withdrew consent during the first cycle and were lost to follow-up. One patient progressed to stage IV disease during induction chemotherapy and did not undergo surgery. Nineteen patients underwent surgery. One patient had undetected stage IV disease (liver) and underwent a palliative R2 resection. Of the 18 remaining patients, 17 had curative R0 resections and one had a palliative R1 resection. A median of 21 lymph nodes (range 1 to 121) were examined histologically. There was one postoperative death. Surgical morbidity did not appear to increase after the neoadjuvant regimen. The median postoperative length of hospital stay was 9 days (range 3 to 75 days). Postoperative pathologic staging yielded 16% T3 lesions compared to 85% before treatment based on clinical staging; postoperative American Joint Committee on Cancer staging yielded 37% stage IIIA disease compared to 70% stage IIIA before treatment. With a median follow-up of 15 months, median survival has not yet been reached. We conclude that CPT-11-based neoadjuvant therapy downstages locally advanced gastric cancer. Further follow-up is necessary to determine the ultimate impact of this combination therapy on recurrence and survival. Presented at the Forty-Second-Annual Meeting of The Society for Surgery of the Alimentary Tract, Atlanta, Georgia, May 20–23, 2001. Supported in part by Pharmacia Oncology and grants NCI/NIH CA 16087 and GCRC M01RR00096. |
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Keywords: | Neoadjuvant therapy gastric cancer downstaging |
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