Osteonecrosis is unrelated to hip anatomy in children with acute lymphoblastic leukemia |
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| Authors: | Colton Smith Wenjian Yang Cheng Cheng Michael D. Neel Ching‐Hon Pui Mary V. Relling Sue C. Kaste |
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| Affiliation: | 1. Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee;2. Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee;3. Department of Orthopaedics, St. Jude Children's Research Hospital, Memphis, Tennessee;4. Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee;5. Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee;6. Department of Radiology, University of Tennessee Health Sciences Center, Memphis, Tennessee |
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| Abstract: | Osteonecrosis is a debilitating toxicity associated with acute lymphoblastic leukemia (ALL) treatment. A recent report associated interindividual differences in hip anatomy with the development of idiopathic osteonecrosis in adults. To evaluate the impact of hip anatomy on the development of therapy‐related osteonecrosis, we retrospectively evaluated the femoral neck‐shaft angle, femoral neck offset, and lateral center‐edge angle using x‐rays of 18 osteonecrosis cases and 46 control children treated for newly diagnosed ALL on a single protocol. Despite adequate statistical power, we found no association between hip anatomy and osteonecrosis. Investigation of other factors contributing to ALL‐associated osteonecrosis is warranted. |
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| Keywords: | acute lymphoblastic leukemia imaging osteonecrosis |
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