福建省鼻咽癌流行病学多种对照配对研究

目的应用多种对照配对的方法进行福建省鼻咽癌病因流行病学研究。方法病例为１１５例原发性鼻咽癌新病例，对照为１１５例非肿瘤、非呼吸系统疾患的病人和１１５例非呼吸系统肿瘤的其他肿瘤病人。结果家用柴草燃料、室内烟尘污染、多食腌芥菜、鼻部疾病史是鼻咽癌发病的主要危险因素，新鲜蔬菜摄入少、吸烟与鼻咽癌有显著关联。结论设立多种对照有利于减少偏倚、控制混杂，通过对不同配对资料ＯＲ值的分析对比，增加了对结果进行判断的依据。

A Matched Study with Various Controls in Nasopharyngeal Carcinoma Epidemiology in Fujian Provinc

Objective A 1:2 matched case-control study was carried out to identify the risk factors of nasopharyngeal carcinoma (NPC)in Fujian province.Methods In this study,115 new,pathologically diagnosed cases of NPC,115 patient controls without cancer and respiratory system diseases, and 115 cancer controls without cancer of respiratory system were investigated. Results The results of one factor analysis,odd ratio(OR),and conditional logistic regression indicated that exposure to domestic woodfire(OR=3.348,P<0.01),exposure to smoke and fume of kitchen,consumption of salted mustard(OR=1. 918,P<0. 01)and nose diseases(OR=4.840,P<0.01) were significant risk factors for NPC.Insufficient intake of vegetables and fruits(OR=1.946, P<0.01),smoking were closely associated with the occurrence of NPC.Conclution Using various typed controls can greatly reduced bias and controlling confounding variables.Estimate of odds ratio was accounted for analysis,then validity of the conclusion was enhanced.