绍兴地区尿碘与甲状腺疾病的关系

目的探讨绍兴地区尿碘与甲状腺疾病的关系。方法测定甲状腺疾病组和正常对照组的血清TSH、FT3、FT4,甲状腺过氧化物酶抗体（TPOAb）,甲状腺球蛋白抗体（TGAb）、甲状腺B超及尿碘。结果正常对照组的尿碘中位数为106μg/L,甲状腺功能异常、甲状腺肿及甲状腺结节患者的尿碘中位数显著高于正常对照组（P〈0.01）,且在甲状腺功能异常、甲状腺肿和甲状腺结节患者中,尿碘浓度〉300μg/L,患者分布频率显著高于对照组（P〈0.01）;尿碘与甲状腺功能（FT3、FT4、TSH、TPO、TGA）及甲状腺结节有无之间无明确的相关性。结论绍兴地区属于碘充足地区,碘过量会增加甲状腺疾病发生率,尿碘测定有助于指导个体化补碘。

Study on the relationship between thyroid disease and urinary iodine in Shaoxing

Objective To investigate the relationship between thyroid disease and urinary iodine in Shaoxing. Methods The thyroid hormone including FT3,FT4,TSH,TPOAb,TGAb and urinary iodine between thyroid disease and normal control were measured . Results The urinary iodine median in normal control in Shaoxing was 106μg/L, the urinary iodine median in thyroid disfunction , goiter, thyroid nodal disease was higher than that in normal control group , and distribution frequency of iodine concentration over 300μg/L was much higher in thyroid diseases group than in control group（ P 〈 0.001 ）. There was no correlation between urinary iodine and thyroid hormones,thyroid nodule . Conclusion The iodine uptake in shaoxing is sufficient, yet the increased uptake of iodine increases the incidence of thyroid diseases. The measurement of urine iodine helps to guide iodine supply in individual.