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Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264 |
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| Authors: | Dittrich Dorothea Keller Christine Ehlers Stefan Schultz Joachim E Sander Peter |
| Affiliation: | aInstitut für Medizinische Mikrobiologie, Universität Zürich, Gloriastrasse 30/32, CH-8006 Zürich, Switzerland bMolecular Infection Biology, Research Center Borstel, Parkallee 22, D-23845 Borstel, Germany cAbteilung Pharmazeutische Biochemie, Pharmazeutisches Institut, Universität Tübingen, Morgenstelle 8, D-72076 Tübingen, Germany dNationales Referenz Zentrum für Mykobakterien, Gloriastrasse 30, CH-8006 Zürich, Switzerland |
| Abstract: | Mycobacterium tuberculosis open reading frame Rv1264 encodes an adenylate cyclase that exhibits its highest enzymatic activity at an acidic pH of 6.0. This is the pH M. tuberculosis encounters in the phagosome. Consequently Rv1264 has been suggested to sense the phagosomal milieu resulting in adaption of M. tuberculosis to its intracellular niche. A targeted knock-out mutant deficient in Rv1264, however, exhibits wild-type virulence. |
| Keywords: | M. tuberculosis Adenylate cyclase Rv1264 Phagosome acidification |
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