神阙隔药灸疗法治疗溃疡性结肠炎的临床观察

目的：观察神阙隔药灸疗法治疗溃疡性结肠炎（UC）的疗效及对自身免疫水平的影响，并探讨其作用机制。方法：将60例UC患者随机分为治疗组（30例）和对照组（30例）。治疗组采用神阙隔药灸疗法，对照组口服柳氮磺胺吡啶片和甲硝唑片，比较两组治疗前后主要症状及肠黏膜病变变化和总疗效，观察血清免疫球蛋白、外周血T细胞亚群与自然杀伤细胞（NK）含量变化。结果：治疗组显效率、总有效率分别为60．0％、86．7％，明显优于时照组的23．3％、66．7％，两组间比较差异有显著性或非常显著性意义（P〈0．05，P〈0．01）。治疗组治疗后IgG显著降低，与对照组治疗后比较差异有显著性意义（P〈0．05）；治疗前后IgA、IgM无明显变化（P〉0．05）。治疗姐治疗后外周血T细胞亚群与NK细胞含量均不同程度增高，增高幅度与疗效呈正相关。结论：神阙隔药灸疗法是治疗溃疡性结肠炎的满意方法，其作用机制可能通过调节机体的免疫功能发挥疗效。

Clinical study on drug-separated moxibustion at Shenque (CV 8) for treatment of ulcerative colitis

OBJECTIVE: To observe the therapeutic effect of drug-separated moxibustion at Shenque (CV 8) on ulcerative colitis (UC) and the influence on autoimmunity level, and study on the mechanism. METHODS: Sixty cases were randomly divided into a treatment group and a control group, 30 cases in each group. The treatment group were treated with drug-separated moxibustion at Shenque (CV 8) and the control group with oral administration of sulphasalazine and metronidazole tablets. The main symptoms, pathological changes of the intestinal mucosa and the total therapeutic effect in the two groups before and after treatment, and the changes of the content of blood serum immunoglobulin, peripheral blood T-cell subgroup and NK cell were observed. RESULTS: The markedly effective rate and the total effective rate in the treatment group were 60.0% and 86.7% respectively, much higher than the control group (P<0.05, P<0.01). IgG content in the treatment group after treatment significantly decreased with a significant difference as compared with the control group (P<0.05); there were no significant differences in IgA and IgM before and after the treatment (P>0.05). After treatment, peripheral blood T-cell subgroup and NK cell in the treatment group increased to a certain extent, which was correlated positively to the therapeutic effect. CONCLUSION: The drug-separated moxibustion at Shenque (CV 8) is a satisfactory method for treatment of ulcerative colitis, and it exerts therapeutic effect possibly through regulating immunological function of the organism.