Successful living‐related renal transplantation in a patient with factor H antibody‐associated atypical hemolytic uremic syndrome

CFH‐Ab‐associated aHUS requires different diagnostic and therapeutic approaches and then the genetically defined aHUS forms. The risk of post‐transplant recurrence with graft dysfunction in CFH‐Ab aHUS is not well documented. It is suggested that recurrence can be expected if a significant CFH‐Ab load persists at the time of transplantation. A pretransplant procedure to reduce CFH‐Ab titer seems reasonable, but accurate recommendations are lacking. Whether further prophylactic interventions after transplantation are necessary has to be decided on an individual basis. We report the case of a late diagnosed CFH‐Ab HUS with initial ESRD and a successful living‐related renal transplantation over a post‐transplant period of four and a half years on the basis of a prophylactic pretransplant IVIG admission.