Bullous pemphigoid after allogeneic hematopoietic stem cell transplantation |
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| Authors: | Keisuke Kato Kazutoshi Koike Chie Kobayashi Shigeruko Iijima Takashi Hashimoto Masahiro Tsuchida |
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| Institution: | 1. Division of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan;2. Department of Dermatology, Mito Saiseikai General Hospital, Mito, Japan;3. Department of Dermatology, Kurume University School of Medicine, Kurume, Japan;4. Kurume University Institute of Cutaneous Cell Biology, Kurume, Japan |
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| Abstract: | Bullous pemphigoid (BP) is an autoimmune skin disorder characterized by subepidermal blisters due to deposit of autoantibody against dermal basement membrane protein. It has been reported that BP can occur after allogeneic hematopoietic stem cell transplantation (HSCT). We describe a patient with BP having autoantibody against BP180 after unrelated‐donor HSCT against T lymphoblastic leukemia. The patient was treated with steroid leading to complete resolution of BP, but T lymphoblastic leukemia progressed rapidly after steroid hormone treatment. Given that immunosuppressant may reduce graft‐versus‐tumor effect, immunomodulatory agents such as nicotinamide and tetracycline, erythromycin, and immunoglobulin may be appropriate as soon as typical blister lesions are seen after HSCT. |
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| Keywords: | bullous pemphigoid hematopoietic stem cell transplantation T‐cell acute lymphoblastic leukemia |
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