5-氨基酮戊酸光动力疗法治疗中、重度痤疮临床观察

目的观察5-氨基酮戊酸光动力疗法(ALA-PDT)治疗中、重度痤疮的临床疗效。方法治疗组26例,予ALA-PDT照射20min,1次/周;对照组20例,予蓝光照射20min,1次/周,同时予口服维胺酯胶囊25mg和外擦克林霉素软膏,2次/d。两组疗程均为4周,并于治疗前及治疗第2,4和6周时判定疗效。结果治疗第4周时,治疗组中、重度痤疮患者的有效率(89.47%和71.43%)分别高于对照组(60.00%和0),差异均有统计学意义(P均<0.05);治疗第6周时,治疗组痊愈率(42.31%)和有效率(92.31%)明显优于对照组(10.00%和55.00%)。结论 ALA-PDT是一种安全、高效和不良反应轻微的治疗中、重度痤疮的新方法。

Clinical Observation of ALA-PDT for Moderate to Severe Acne Vulgaris

Objective To observe the clinical efficacy of ALA-PDT for treatment of moderate to severe acne vulgaris.Methods Twenty-six cases were assigned to the trail group,and treated by ALA-PDT weekly,twenty minutes for each time;20 cases were assigned to the control group,and treated by blue light weekly,twenty minutes for each time.Meanwhile the control group were treated viaminate capsules 25mg orally and topic clindamycin ointment,twice a day.Course of treatment in both group were 4 weeks.To evaluate the clinical efficacy of pre and post treatment(2nd,4th,6th week).Results On the 4th week,the effective rate(89.47% and 71.43%) of moderate to severe acne vulgaris in the trail group,was higher than that of the control group(60.00% and 0),The difference was statistically significant(all P<0.05);On the 6th week,the cure rate(42.31%)and effective rate(92.31%) of trail group was higher than that of control group(cure rate 10.00%,effective rate 55.00%).Conclusion Due to safety,effectiveness and mild adverse reaction,ALA-PDT might become a new method in the treatment of moderate to severe acne vulgaris.