中医辨证配合依巴斯汀治疗慢性荨麻疹的临床观察

目的探索一套具有良好疗效的慢性荨麻疹治疗方案。方法符合纳入标准者148例,其中治疗组98例,对照组50例。治疗组根据辨证结果予相应的中药汤剂200mL口服,2次/d;风团较多,瘙痒剧烈者,同时服用依巴斯汀片10mg,每夜服用1次,并随着皮损减轻而逐渐减量至停用。对照组只予同治疗组剂量的依巴斯汀递减疗法口服。1个月为1疗程,6个疗程结束后,观察两组的近期疗效,并对治愈的患者于治疗后的1个月、3个月、6个月三个时间点进行随访,观察两组的远期疗效。结果治疗组治愈60例,有效率84.69%,对照组分别为15例和54.00%,差异有统计学意义(P<0.01);远期疗效观察,治疗组治愈的60例全部达到远期缓解,未见复发,对照组治愈的15例远期缓解率53.33%,中期缓解率26.67%,短期缓解率6.67%,复发率13.33%。结论中医辨证配合依巴斯汀治疗慢性荨麻疹疗效好,显著优于单纯依巴斯汀对照组。

Clinical Study on Syndrome Differentiation of TCM with Ebastine for Chronic Urticaria

Objective To explore and summarize a suit of therapeutic regimen for the treatment of chronic urticaria(CU). Methods One hundred and forty-eight cases meeting the criteria were included:98 cases in the treatment group, 50 in the control group. The treatment group was given corresponding decoction with differentiation of symptoms and signs, 200mL one time, bid. Patients with severe pruritus and intense itching were given ebastine as well, 10mg, qn., which was gradually reduced or stopped if the lesions lightened or disappeared. The control group was only treated with ebastine in the same way as in the treatment group. One month was regard as a course of treatment, and six courses were observed. After six courses of treatment, the therapeutic effect of the two groups was observed, and follow-up visits were made to observe prostecdtive efficacy one month, three months and six months after treatment. Results Sixty cases from the treatment group were cured, the effective rate reaching 84.69%; 15 in the control group were cured, the effective rate at 54.00%. The difference in the curative effects in the 2 groups has very notable significance(P<0.01). The observation of the long-term curative effect showed none of the 60 cured cases in the treatment group recurred. The long-term remission rate of the 15 cured cases in the control group was only 53.33%, the mid-term remission rate at 26.67%, the short-term remission rate at 6.67%, the recurrence rate at 13.33%. Conclusion The syndrome differentiation of TCM and ebastine were obviously more effective for the treatment of chronic urticaria than ebastine alone.