二苯环丙烯酮治疗斑秃16例疗效观察

目的观察斑秃患者局部外用二苯环丙烯酮(DPCP)治疗的临床疗效。方法应用DPCP治疗16例斑秃患者,2%DPCP外搽秃发区致敏,1周后用0.001%DPCP外搽患者头皮,每周1次,并据患者反应增加浓度观察其治疗反应及副作用,并与局部外用米诺地尔酊2次/d进行对照。结果治疗组坚持治疗的11例患者中,8例出现终毛生长,有效率为72.73%,达到良好反应的中位时间为(9.07±3.96)月,停止治疗后复发率为25.00%,12.50%患者出现较严重副作用。对照组13例坚持治疗,4例患者出现终毛生长,有效率30.77%,复发率为25.00%。治疗组疗效明显优于对照组(P<0.05)。结论 DPCP治疗斑秃有效率高,安全性相对较好,是值得推荐的一种有效治疗方法。

Efficacy of Immunotherapy with Diphenylcyclopropenone in the Treatment of Alopecia Areata

Objective To assess the efficacy of diphenylcyclopropenone(DPCP)in the treatment of alopecia areata. Methods Sixteen patients with alopecia areata were treated with DPCP. After sensitization with 2% DPCP, progressively higher concentrations beginning at 0.001% were applied weekly. The response rate and side-effects were studied. Sixteen patients in control group were treated with minoxidil two times per day. Results Eight patients responded among the 11 completing therapy(72.73%)in treatment group. The mean duration of treatment until excellent response was 9.07±3.96 months. Two patients (25.00%) had a relapse during follow-up. Significant side-effects were observed in 12.50% of patients. Four patients responded among the 13 completing therapy(30.77%)in control group. And the relapse rate was 25.00%. The response rate in treatment group was significantly higher than those in control group(P<0.05). Conclusion Topical immunotherapy with DPCP is an effective and relatively safe treatment for alopecia areata.