复方泽漆冲剂对不同证型寻常性银屑病患者IL-23/Th 17细胞轴的影响

目的观察复方泽漆冲剂对血热、血瘀、血燥三型寻常性银屑病(PV)患者血清中IL-17,IL-22和IL-23的影响,探讨复方泽漆冲剂对三型PV患者IL-23/Th17细胞轴的影响。方法三型PV患者均口服复方泽漆冲剂,每型患者均为20例,疗程4周,采用ELISA法对60例PV患者治疗前后和10例健康对照组的血清中IL-17,IL-22和IL-23水平进行检测。结果 60例PV患者血清中的IL-17,IL-22和IL-23的水平治疗前、后均明显高于健康对照组(P均<0.01)。三型患者治疗后的IL-17,IL-22和IL-23的水平与治疗前相比,均明显下降,(P均<0.01)。血热型治疗前、后的IL-17,IL-22和IL-23分别为23.369±2.402pg/mL,12.753±2.014pg/mL;200.694±20.087pg/mL,135.772±10.551pg/mL;23.124±1.886pg/mL,16.156±2.481pg/mL。血瘀型治疗前后的IL-17,IL-22和IL-23分别为23.456±2.142pg/mL,14.944±1.912pg/mL;200.554±19.725pg/mL、146.112±16.523pg/mL;22.562±1.768pg/mL,14.512±2.111pg/mL。血燥型治疗前后的IL-17,IL-22和IL-23分别为24.556±1.653pg/mL,16.836±2.161pg/mL;204.754±19.428pg/mL,155.702±11.489pg/mL;23.362±2.462pg/mL、12.876±2.462pg/mL。结论复方泽漆冲剂能降低三型PV患者血清中IL-17,IL-22和IL-23的水平,其中对血热型的作用最强,对血瘀型次之,对血燥型最弱。

Ze Qi Granule Treatment on Diffentent TCM Syndrome Types of PV Patients Effect on IL-23/Th 17 Cell Axis

Objective Through the observation of ZeQi Granule influence on IL-17,IL-22,IL-23 on blood heat,blood stasis, blood dryness three types of PV patients, ZeQi Granule treatment on diffentent TCM syndrome types of PV patients influences on IL-23/Th17 cell axis. Methods Three types of PV patients are all on Ze Qi Granule per oral for four weeks. Each type involves 20 patients.Levels of IL-17,IL-22,IL-23 in serum of 60patients with PV before and after treatment.,and 10 heathy persons as controls were detected by ELISA. Results Serum IL-17, IL-22, IL-23 of 60 PV patients were significantly higher than healthy controls(P<0.01). After treatment the levels of IL-17, IL-22, IL-23 in three types of PV patients were significantly lower than before and are all P<0.01. Serum IL-17, IL-22, IL-23 of blood heat patients before and after treatment respectively are 23.369±2.402 pg/mL,12.753±2.014 pg/mL;200.694±20.087 pg/mL,135.772±10.551 pg/mL;23.124±1.886 pg/mL,16.156 ±2.481 pg/mL. Serum IL-17, IL-22, IL-23 of blood stasis patients before and after treatment respectively are 23.456±2.142 pg/mL,14.944±1.912 pg/mL;200.554 ±19.725 pg/mL,146.112±16.523 pg/mL;22.562±1.768 pg/mL, 14.512±2.111 pg/mL。Serum IL-17, IL-22, IL-23 of blood dryness patients before and after treatment respectively are24.556±1.653 pg/ml,16.836±2.161 pg/mL;204.754±19.428 pg/mL,155.702±11.489 pg/mL;23.362±2.462 pg/mL.12.876±2.462 pg/mL. Conclusion ZeQi granule can decrease serum IL-17, IL-22, IL-23 of three types of PV patients, The effect on blood heat type is the strongest, followed by the blood stasis type,and the last blood dryness type.