Erectogenic effect of the selective phosphodiesterase type 5 inhibitor, DA-8159 |
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Authors: | Tae Young Oh Kyung Koo Kang Byoung Ok Ahn Moohi Yoo Won Bae Kim |
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Affiliation: | Research Laboratories, Dong-A Pharm. Co, Ltd, Yongin, Kyunggi, Korea. solemiooh@donga.co.kr |
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Abstract: | DA-8159, a new phosphodiesterase 5 inhibitor, was assessed for its erectogenic potential by a penile erection test in rats, the relaxation of isolated rabbit corpus cavernosum (CC), and estimation of the intracavernous pressure (ICP) in the anesthetized dog. Oral administration of DA-8159 (0.3 to 1 mg/kg) increased the number of erections in rats with increasing dosage, with the highest penile erection index at 10 mg/kg. DA-8159 induced the relaxation of phenylephrine (PHE)-induced contractions in the rabbit CC and decreased the IC50 of the nitric oxide donor sodium nitroprusside (SNP) in a dose-dependent fashion. In pentobarbital-anesthetized dogs, the intravenous administration of DA-8159 (1 approximately 300 g/kg) potentiated the increase in ICP induced by the intracavernosal SNP in a dose-related manner. These findings suggest that DA-8159 has significant therapeutic potential in the treatment of erectile dysfunction. |
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Keywords: | DA-8159 Phosphodiesterase 5 inhibitor Rabbit corpus cavernosum Intracavernous pressure (ICP) Penile erection index (PEI) Erectile dysfunction (ED) |
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