葛根素治疗急性脑梗死的疗效及机制探讨——附22例资料分析

目的：观察葛根素注射液对急性脑梗死（ＡＣＩ）的治疗作用。方法：４４例ＡＣＩ患者随机分为两组，葛根素治疗组（Ａ组）２２例应用葛根素５００ｍｇ加５％葡萄溶液静脉滴注。每日１次，共１４天，低分子右旋糖酐组（Ｂ组）２２例应用低分子右旋糖酐５００ｍＬ，方法与疗程同Ａ组，分别于治疗前气治疗２疗程后作神经功能缺损评分：同时观察血流动力学，心电图、梗死灶体积大小等指标的变化以评定临床疗效。结果：治疗后Ａ组有效率８

Observation on clinical efficacy of puerarin in the treatment of acute cerehral inrarction

Objective:To observe the clinical efficacy of puerarin in the treatment of acute cerebral infarction(ACI),Methods: 44 patients of ACI were randomly divided into two group.Patient in A group (n = 22 ) were treatedwith puerarin (500 mg/d ), while subject in B group (n= 22) were treated with dextram (500 mL,/d) for a course of14 days. The neurological deficit scores, hemorrheological indexes, electrocardiogram and size of infarction foci of allpatients were compared before and after treatment to evaluate the clinical efficacy.Results: The overall effective rateof A group was remarkable higher than that of B group (82% vs 45%, P<0. 01).Plasma viscosity, whole blood vis-cosity, plasma fibrinogen content and size of infarction foci were significantly reduced in A group. Conclusion:Puerarincan significant1y improve the hemorrheological indexes of ACl patients. it is a safe and effective drug and can be usedas an alternative method in the treatment of ACI.