| 奥沙利铂对结肠癌细胞XIAP表达及凋亡的影响 |
| |
| 引用本文： | 赵剑波,夏宗江. 奥沙利铂对结肠癌细胞XIAP表达及凋亡的影响[J]. 齐齐哈尔医学院学报, 2008, 29(8): 899-900 |
| |
| 作者姓名： | 赵剑波 夏宗江 |
| |
| 作者单位： | 河南省许昌市人民医院普外科,461000;中南大学湘雅三院移植医学研究院,长沙 |
| |
| 摘 要： | 目的 研究奥沙利铂对人结肠癌细胞株SW1116中XIAP表达及凋亡的影响,探讨其诱导凋亡的作用机制。方法 应用流式细胞仪检测XIAP表达及凋亡的情况。结果 奥沙利铂对XIAP表达有明显的抑制作用（P〈0.05）,凋亡率明显高于对照组（P〈0.01）。结论 奥沙利铂具有抑制结肠癌细胞株SW1116中XIAP表达,诱导结肠癌细胞凋亡作用,其机制与抗凋亡相关基因表达减弱有关。
|
| 关 键 词： | 奥沙利铂 结肠癌 凋亡抑制蛋白 凋亡 |
| 修稿时间： | 2008-01-03 |
Effect of XIAP expression and apoptosis of human colorectal carcinoma cell line SW1116 induced by oxaliplatin |
| |
| ZHAO Jian-bo,et al.. Effect of XIAP expression and apoptosis of human colorectal carcinoma cell line SW1116 induced by oxaliplatin[J]. Journal of Qiqihar Medical College, 2008, 29(8): 899-900 |
| |
| Authors: | ZHAO Jian-bo et al. |
| |
| Affiliation: | ZHAO Jian-bo,et al. (Department of GENSURG,People＇s Hospital of Xuchang,Xuchang,Henan 461000 China) |
| |
| Abstract: | Objective To study the effects of expression of XIAP and apoptosis of human colorectal carcinoma cell line SW1116 cells induced by oxaliplatin and to investigate its mechanism. Methods Expression of XIAP and apoptosis were analyzed using flow cytometry. Results Oxaliplatin could conspicuously inhibit the expression of XIAP of SW1116 cells (P<0.01), meanwhile the apoptosis rate was obviously increased (P<0.05). Conclusions Oxaliplatin can inhibit the expression of XIAP and induce apoptosis increasing of Human Colorectal Carcinoma Cell Line SW1116 cells. The apoptosis was related to the down - regulation apoptotic protein XIAP. |
| |
| Keywords: | Oxaliplatin Colorectal carcinoma Cell line SW1116 XIAP Apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
