| 穗花杉双黄酮大鼠在体肠吸收动力学的研究 |
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| 引用本文： | 韦丹丹,陈 骁,赵建娟,胡晓龙,熊 非,汪 豪. 穗花杉双黄酮大鼠在体肠吸收动力学的研究[J]. 药学与临床研究, 2017, 25(4): 282-285 |
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| 作者姓名： | 韦丹丹 陈 骁 赵建娟 胡晓龙 熊 非 汪 豪 |
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| 作者单位： | 中国药科大学 天然药物化学教研室,中国药科大学 天然药物化学教研室,中国药科大学 天然药物化学教研室,中国药科大学 天然药物化学教研室,东南大学 生物科学与医学工程学院,中国药科大学 天然药物化学教研室 |
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| 基金项目： | 国家自然科学基金（81573309） |
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| 摘 要： | 采用大鼠在体单向肠灌流实验模型，用HPLC-UV法测定灌流液中药物浓度，研究穗花杉双黄酮肠吸收动力学。结果表明穗花杉双黄酮在十二指肠、空肠、回肠和结肠的吸收速率常数（Ka）、药物表观渗透系数（Papp）差异无统计学意义（P>0.05），提高药物浓度的吸收速率常数基本保持不变。在大鼠各肠段均有吸收，无特定吸收部位，吸收机制为被动扩散。
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| 关 键 词： | 穗花杉双黄酮；在体；肠吸收；单向肠灌流 |
| 收稿时间： | 2017-04-24 |
| 修稿时间： | 2017-08-11 |
Studies on the Intestinal Absorption Kinetics of Amentoflavone in Rats |
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| Wei Dandan,Chen Xiao,Zhao Jianjuan,Hu Xiaolong,Xiong Fei and Wang hao. Studies on the Intestinal Absorption Kinetics of Amentoflavone in Rats[J]. Pharmacertical and Clinical Research, 2017, 25(4): 282-285 |
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| Authors: | Wei Dandan Chen Xiao Zhao Jianjuan Hu Xiaolong Xiong Fei Wang hao |
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| Affiliation: | Departure of Natural Medicinal Chemistry, China Pharmaceutical University,Departure of Natural Medicinal Chemistry, China Pharmaceutical University,Departure of Natural Medicinal Chemistry, China Pharmaceutical University,Departure of Natural Medicinal Chemistry, China Pharmaceutical University,School of Biological Science and Medical Engineering, Southeast University,Departure of Natural Medicinal Chemistry, China Pharmaceutical University |
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| Abstract: | This study is to establish an in situ single-way intestinal perfusion model, in order to study the intestinal absorption kinetics of amentoflavone. The concentraion of amentoflavone in the perfusate was determined by HPLC-UV. The results showed that the values of absorption rate constant (Ka), and the apparent absorption coefficient (Papp) of amentoflavone at duodenum, jejunum, ileum and colon were not significantly different (P>0.05), the absorption rate constant kept unchanged with the rise of drug concentrations. Amentoflavone is absorbed in all intestine segments of rats with no special absorption window, and the absorptive mechanism may be passive diffusion. |
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| Keywords: | Amentoflavone In vivo Intestinal absorption One-way intestinal perfusion |
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