| 伏立康唑致1例肾移植患者他克莫司血药浓度升高 |
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| 引用本文： | 陈 进,高 杰.伏立康唑致1例肾移植患者他克莫司血药浓度升高[J].药学与临床研究,2015,23(6):599-600. |
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| 作者姓名： | 陈 进 高 杰 |
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| 作者单位： | 江苏省海安县人民医院药剂科，海安 226600,苏州大学附属第一医院药学部，苏州 215006 |
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| 摘 要： | 临床药师在查房中发现肾移植患者他克莫司血药浓度过高，分析原因为治疗其真菌感染的伏立康唑抑制了他克莫司的代谢酶细胞色素CYP3A的活性所致。药师由此提出减少他克莫司用量（当他克莫司与伏立康唑联合用药时，他克莫司的剂量调整为原来的1/3）及监测其血药浓度，建议被采纳，患者的他克莫司血药浓度重新达到目标范围。
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| 关 键 词： | 他克莫司 血药浓度 伏立康唑 |
| 收稿时间： | 2015/8/26 0:00:00 |
| 修稿时间： | 2015/11/20 0:00:00 |
Pharmaceutical Care on Voriconazole Raised Tacrolimus Blood Concentration in a Renal Transplant Patient |
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| CHEN Jin and GAO Jie.Pharmaceutical Care on Voriconazole Raised Tacrolimus Blood Concentration in a Renal Transplant Patient[J].Pharmacertical and Clinical Research,2015,23(6):599-600. |
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| Authors: | CHEN Jin and GAO Jie |
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| Institution: | Department of Pharmacy, Haian County People''s Hospital of Jiangsu Province, Haian, Jiangsu 226600 and Department of Pharmacy, the First Affiliated Hospital of Soochow University, Soochow, Jiangsu 215006 |
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| Abstract: | Voriconazole induced blood drug concentration raise of tacrolimus in a renal transplant patient was found by clinical pharmacists. The reason, the mechanism and the interaction of drugs were analyzed by clinical pharmacists, and finally rational proposals were given for the patient. Clinical pharmacists'' medication intervention successfully helped the patient reached target steady-state blood drug concentration. Thus, clinical pharmacists should give the medication instructions to patients who receive tacrolimus after renal transplantation and monitor closely the blood drug concentration of tacrolimus during the process of treatment. |
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| Keywords: | Tacrolimus Plasma concentration Voriconazole |
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