| 星点设计法优化盐酸伊托必利分散片处方 |
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| 引用本文： | 岳 莉,王江涛,龙连清,苏 亮.星点设计法优化盐酸伊托必利分散片处方[J].药学与临床研究,2015,23(6):555-557. |
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| 作者姓名： | 岳 莉 王江涛 龙连清 苏 亮 |
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| 作者单位： | 迪沙药业集团，山东威海 264200,迪沙药业集团，山东威海 264200,迪沙药业集团，山东威海 264200,迪沙药业集团，山东威海 264200 |
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| 摘 要： | 目的：采用湿法制粒工艺制备盐酸伊托必利分散片。方法：以崩解时间、溶出度和混悬系数为评价指标，对辅料用量进行响应面分析法优化设计。结果与结论：处方最优工艺参数：乳糖占44.78%，微晶纤维素占25.75%，交联聚维酮占5.53%。该工艺下样品的崩解时间、溶出度和混悬系数等各指标参数达到较理想结果，符合分散片的质量要求。
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| 关 键 词： | 盐酸伊托必利 分散片 响应面分析法 |
| 收稿时间： | 2015/5/19 0:00:00 |
| 修稿时间： | 2015/7/27 0:00:00 |
Optimization of the Preparation of Itopride Hydrochloride Dispersible Tablet Using Response Surface Methodology |
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| YUE Li,WANG Jiang-tao,LONG Lian-qing and SU Liang.Optimization of the Preparation of Itopride Hydrochloride Dispersible Tablet Using Response Surface Methodology[J].Pharmacertical and Clinical Research,2015,23(6):555-557. |
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| Authors: | YUE Li WANG Jiang-tao LONG Lian-qing and SU Liang |
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| Institution: | DiSha Pharmaceutical Group, Weihai, Shandong 264200,DiSha Pharmaceutical Group, Weihai, Shandong 264200,DiSha Pharmaceutical Group, Weihai, Shandong 264200 and DiSha Pharmaceutical Group, Weihai, Shandong 264200 |
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| Abstract: | Objective: To prepare itopride hydrochloride dispersible tablets by wet granulation. Methods: The formulation of itopride hydrochloride dispersible tablets was optimized in terms of disintegrating time, dissolution and suspensibility by response surface methodology designing. Results and Conclusion: The optimized formulation of the itopride hydrochloride dispersible tablets contained lactose 44.78%, microcrystalline cellulose 25.75% and cross-linked polyvinyl pyrrolidone 5.53%. Under the optimized formulation, disintegration time, dissolution and suspension coefficient achieved desirable results, which meets the quality standards. |
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| Keywords: | Itopride hydrochloride Dispersible tablets Response surface methodology |
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