Feline polymorphonuclear leukocytes respond chemotactically to leukotriene B4 and activated serum but not to F-met-leu-phe |
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| Authors: | Gary D. Gray Greta M. Ohlmann Douglas R. Morton Robert G. Schaub |
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| Affiliation: | (1) From Infectious Diseases Research and Atherosclerosis and Thrombosis Research, The Upjohn Company, 49001 Kalamazoo, MI |
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| Abstract: | The chemotactic response of feline polymorphonuclear leukocytes (PMNs) to three types of chemoattractants was studied. Feline PMNs responded to leukotriene B4 as well as to agarose-activated autologous and homologous serum. However, no response was obtained to N-formylmethionylleucylphenylalanine (FMLP), and four similar peptides that activate the FMLP receptor (N-formylnorleucylleucylphenylalanine, N-formylmethionylphenylalanine, methionylleucylphenylalanine, and pepstatin.) Thus, feline PMNs are similar to equine, porcine, bovine and canine PMNs which also do not respond chemotactically to these peptides. |
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