| 哒嗪酮类新化合物9612的抗血小板聚集作用 |
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| 引用本文： | 马兵,阚启明,王进,王世久.哒嗪酮类新化合物9612的抗血小板聚集作用[J].沈阳药科大学学报,2000,17(6):441-443. |
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| 作者姓名： | 马兵 阚启明 王进 王世久 |
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| 作者单位： | 沈阳药科大学药学系沈阳 110015 |
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| 摘 要： | 研究了新型哒嗪酮类化合物 96 12对家兔和大鼠血小板聚集的影响 .结果发现 ,96 12在体外能明显抑制花生四烯酸 (AA) ,腺苷二磷酸 (ADP)和凝血酶 (thrombin)诱导的家兔血小板聚集 ,其IC50 分别为 3 2 0 ,9 44和 7 10 μmol/L .96 12 .灌胃给药 (ig) ,能显著抑制AA和ADP诱导的大鼠血小板聚集 ,其作用与同等剂量 (15 0mg/kg)的阿斯匹林 (ASA)相比无明显差异 (P >0 0 5 ) .
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| 关 键 词： | 哒嗪酮 血小板 血小板聚集 花生四烯酸 腺苷二磷酸 凝血酶 |
| 修稿时间： | 2000年4月21日 |
Effects of a Novel Pyridazinone 9612 on Platelet Aggregation |
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| Ma Bing,Kan Qiming,Wang Jin,Wang Shijiu.Effects of a Novel Pyridazinone 9612 on Platelet Aggregation[J].Journal of Shenyang Pharmaceutical University,2000,17(6):441-443. |
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| Authors: | Ma Bing Kan Qiming Wang Jin Wang Shijiu |
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| Institution: | Ma Bing,Kan Qiming,Wang Jin,Wang Shijiu Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110015 |
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| Abstract: | This paper has revealed the effects of a novel pyridazinone(9612)on the platelet aggregation of rabbits and rats.In the platelet-rich plasma of rabbits,9612 remarkably inhibited platelet aggregation induced by arachidonic acid(AA),adenosine-5-diphosphate(ADP)or thrombin in vitro ,with the IC 50 values of 3 20,9 44 or 7 10 μmol/L respectively.9612(ig) was also able to inhibit the rat platelet aggregation induced by AA or ADP;Compared with equivalent dosage of saspirin(ASA)there was no significant difference( P >0 05).It is showed that 9612 is an effective platelet aggregating inhibitor,its mechanism needs to be investigated further. |
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| Keywords: | pyridazinone platelet platelet aggregation arachidonic acid adenosine-5-diphosphate thrombin |
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