| 神经病理性疼痛的受体机制研究进展 |
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| 引用本文： | 焦悦,郭建友,李守业,朱妍,李昌煜.神经病理性疼痛的受体机制研究进展[J].中国药理学通报,2012,28(5):593-597. |
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| 作者姓名： | 焦悦 郭建友 李守业 朱妍 李昌煜 |
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| 作者单位： | 1. 浙江中医药大学,浙江,杭州,310053
2. 中国科学院心理研究所心理健康重点实验室,北京,100101 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 神经病理性疼痛是一类治疗难度非常大的慢性疼痛,由于其发病机制尚未完全阐明,目前尚缺乏理想的治疗药物。以往研究显示,神经病理性疼痛与阿片受体、NMDA受体等有关,现阶段又发现多种受体参与了神经病理性疼痛的病理生理过程。该文综述了嘌呤与嘧啶受体、GABA受体、PAF受体等在神经病理性疼痛发病机制中的作用。
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| 关 键 词： | 神经病理性疼痛 嘌呤与嘧啶受体 GABA受体 PAF受体 激动剂 拮抗剂 机制 |
Progress in the receptor mechanism of neuropathic pain |
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| JIAO Yue
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GUO Jian-you
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LI Shou-ye
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ZHU Yan
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LI Chang-yu.Progress in the receptor mechanism of neuropathic pain[J].Chinese Pharmacological Bulletin,2012,28(5):593-597. |
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| Authors: | JIAO Yue GUO Jian-you LI Shou-ye ZHU Yan LI Chang-yu |
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| Institution: | 1(1.Zhejiang Chinese Medical University,Hangzhou 310053,China;2.Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China) |
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| Abstract: | Neuropathic pain is a class of chronic pain which is difficult to treat.Since the pathogenesis has not been clarified completely,the ideal and satisfactory medication is not available currently.Previous studies have proved some relevance among neuropathic pain,opioid receptor,NMDA receptors etc.Recently,a variety of receptors are discovered to be involved in the pathological physiology process of neuropathic pain.This review demonstrates the role of purine and pyrimidine receptors,GABA receptors and PAF receptors in the pathogenesis of neuropathic pain. |
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| Keywords: | neuropathic pain purine and pyrimidine receptors GABA receptor PAF receptor agonists antagonists mechanism |
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