| 自噬调控慢性粒细胞白血病干细胞功能的研究进展 |
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| 引用本文： | 朱玲燕,葛卫红,葛宇清,张光霁,程汝滨.自噬调控慢性粒细胞白血病干细胞功能的研究进展[J].中国中药杂志,2017,42(23):4542-4547. |
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| 作者姓名： | 朱玲燕 葛卫红 葛宇清 张光霁 程汝滨 |
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| 作者单位： | 浙江中医药大学 药学院, 浙江 杭州 310053,浙江中医药大学 药学院, 浙江 杭州 310053,浙江中医药大学 第一临床医学院, 浙江 杭州 310006,浙江中医药大学 药学院, 浙江 杭州 310053,浙江中医药大学 药学院, 浙江 杭州 310053 |
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| 基金项目： | 国家自然科学基金特别项目（81641002）；中国中医科学院十三五重点领域项目（Z2017021） |
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| 摘 要： | 白血病干细胞具有自我更新和多向分化的潜能,参与了慢性粒细胞白血病的病程发展,是导致患者耐药和复发的重要原因之一。自噬作为一种保守的溶酶体降解途径,参与细胞内降解和循环途径,在维持细胞内环境稳态和功能方面起着关键作用。研究表明,自噬参与了白血病干细胞的分化调控,与慢性粒细胞白血病的化疗敏感性密切相关。该文就自噬对慢性粒细胞白血病化疗敏感性和干细胞功能的调控进行了系统综述,为靶向自噬的抗白血病药物的开发奠定基础。
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| 关 键 词： | 自噬 慢性粒细胞白血病 白血病干细胞 化疗敏感性 研究进展 |
| 收稿时间： | 2017/5/27 0:00:00 |
Progress of regulation of leukemia stem cells of chronic myeloid leukemia by autophagy |
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| ZHU Ling-yan,GE Wei-hong,GE Yu-qing,ZHANG Guang-ji and CHENG Ru-bin.Progress of regulation of leukemia stem cells of chronic myeloid leukemia by autophagy[J].China Journal of Chinese Materia Medica,2017,42(23):4542-4547. |
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| Authors: | ZHU Ling-yan GE Wei-hong GE Yu-qing ZHANG Guang-ji and CHENG Ru-bin |
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| Institution: | College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China,College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China,The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310006, China,College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China and College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China |
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| Abstract: | Leukemia stem cells (LSC) that were found in chronic myeloid leukemia (CML) responsible for the abnormal proliferation with the potential of self-renewal and multi-directional differentiation are involved in the pathophysiological process for drug resistance and relapse of CML. Autophagy, a conservative lysosomal degradation process that mediates cell degradation and recycling process, plays crucial roles in maintaining the homeostasis and function of intracellular environment. Recent studies suggested that autophagy is involved in the regulation of LSC differentiation and also closely related to the chemo-sensitivity of CML. In this review, we focused on the role of autophagy on chemotherapy sensitivity of CML as well as the leukemia stem cell function for the development of new anti-leukemia drugs |
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| Keywords: | autophagy chronic myeloid leukemia leukemia stem cells chemosensitivity research progress |
| 本文献已被 CNKI 等数据库收录！ |
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