冠状动脉慢血流现象与血液生化指标的相关性分析

目的:探讨冠状动脉慢血流现象(coronary slow flow phenomenon,CSFP)与血尿酸(UA)、同型半胱氨酸(Hcy)、红细胞压积(Hct)及红细胞分布宽度(RDW)的相关性。方法:对因胸闷、胸痛症状行冠状动脉造影术(coronary angiography,CAG)住院患者的病例资料进行回顾性分析,选择其中CAG显示心外膜冠状动脉无明显狭窄但存在CSFP的121例患者作为CSFP组(SCF组),另将CAG证实心外膜冠状动脉完全正常且血流正常的606例患者设为正常血流组(NCF组)。比较两组患者UA、Hcy、Hct及RDW的差异,并分析CSFP与上述指标、UA与其他生化指标间的相关性。结果:SCF组UA、Hcy、Hct水平均较NCF组升高(P0.001);两组RDW水平差异无统计学意义。条件Logistic回归分析发现,UA、Hcy、Hct均为CSFP的危险因素;Spearman相关及偏相关性分析示UA与Hcy正相关(P0.001)。结论:UA、Hcy、Hct是CSFP发生的危险因素,UA与Hcy可能协同促进CSFP的发生发展。

The correlation analysis between coronary slow flow phenomenon and blood biochemical parameters

objective: to study the correlation between the coronary slow flow phenomenon (Coronary slow flow phenomenon, CSFP) and blood uric acid (UA), homocysteine (Hcy), hematocrit (Hct) and red cell distribution width (RDW). Methods: The symptoms including chest pain and coronary arteriography (coronary angiography, CAG) patients were analyzed retrospectively, the CAG showed no obvious epicardial coronary artery stenosis but coronary slow flow phenomenon which were classified into slow coronary blood flow group (SCF group, 121 cases); CAG showed that normal coronary artery and normal blood flow were set up as normal coronary artery (NCF) (NCF group, 606 cases). The differences of blood biochemical indexes between the two groups were compared, and the related factors were analyzed by Mann-Whitney U test, regression analysis and Spearman correlation analysis (Logistic). Results: 1. the levels of serum uric acid (UA), blood homocysteine (Hcy) and hematocrit (Hct) in SCF group were significantly higher than those in group NCF; 2. The red blood cell distribution width (RDW) showed no difference between SCF group and NCF group; 3. It showed that UA, Hcy and Hct were the independent risk factors for CSFP by using two classification Logistic regression analysis; 4. There was a positive correlation between uric acid and homocysteine in correlation and partial correlation analysis by Pearman test. Conclusions: 1. the levels of UA, Hcy and Hct in SCF group were significantly higher than those in NCF group. 2. UA, Hcy and Hct were the risk factors for CSFP; 3. There was a synergistic effect between UA and Hcy in promoting the development of CSFP.