胰岛素治疗角膜损伤的研究进展

胰岛素作为一种蛋白激素具有促进糖原、脂类及蛋白质合成的作用,但近年的大量研究证实,其还具有抗炎、抗凋亡的重要生物学作用。角膜损伤后其病理改变与炎性反应和病理性凋亡密切相关,而胰岛素通过与受体结合,激活磷脂酰肌醇-3激-酶（PI3K）途径和丝裂原激活蛋白激酶（MAPK）途径,参与角膜细胞损伤的炎症与凋亡调控。就胰岛素及其受体与底物的化学结构、信号传导机制及其在眼表分布、角膜损伤治疗的研究进行综述。

Research advancement in treatment of corneal injury by insulin

Nowadays many evidences showed that insulin is a protein hormone with anti-inflammation and anti-apoptosis as well as promoting the synthesis of glycogen,lipid and protein. Therefore,more studies are concerning the new role of insulin. The pathological change of cornea injury is closely related to the pathological apoptosis and inflammatory response, and insulin can regulate inflammation and apoptosis in the corneal injury by binding with the receptor, acting phosphatidylinosi-tol-3-kinase （PI3 K） pathways and mitogen-activated protein kinase （MAPK） channels. This review focus on the chemical structure of insulin, signal pathway of insulin,insulin receptor and its substrate, as well as its distribution of ocular surface and the study of treatment of corneal injury.