B cell antigen receptor signaling 101 |
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Authors: | Dal Porto Joseph M Gauld Stephen B Merrell Kevin T Mills David Pugh-Bernard Aimee E Cambier John |
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Institution: | Integrated Department of Immunology, University of Colorado Health Science Center and National Jewish Medical Research Center, 1400 Jackson Street, Denver, CO 80206, USA. |
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Abstract: | All cells continually survey their environment and make decisions based on cues encountered. This requires specific receptors that detect such cues, then transduce signals that initiate the appropriate responses. B lymphocytes provide an archetypal model for such 'adaptive' cellular responses, where signals transmitted by the B cell Ag-receptor (BCR) influence not only cellular selection, maturation, and survival, but are imperative in generating the ultimate effector function of B cells, i.e. antibody production. While other extracellular stimuli and their cognate receptor signals can also influence B cell development, BCR-mediated signals and the way in which they are integrated and regulated are paramount in defining the cell's physiological fate. |
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