流感嗜血杆菌临床分布与耐药性分析

目的了解流感嗜血杆菌的临床分布及其耐药性。方法采用卫星实验对154株流感嗜血杆菌进行鉴定，纸片琼脂扩散（K—B）法进行药敏试验，采用头孢硝噻吩滤纸片法进行β-内酰胺酶检测。结果154株流感嗜血杆菌科室分布以感染科（40株）、神经呼吸内科（32株）、老年中医科（30株）为主；对氨苄西林、环丙沙星、阿奇霉素和复方新诺明耐药性较高，耐药率均大于60．00％，美罗培南和氨曲南的抗菌活性好，耐药率分别为0．00％、8．44％；流感嗜血杆菌产争内酰胺酶率为20．13％。结论流感嗜血杆菌耐药率高且具有多重耐药性，临床应加强监测并根据药敏结果合理选用抗菌药物进行治疗。

Analysis on clinical distribution and antimicrobial resistance of hemophilies influenzae

Objective To investigate the clinical distribution and antimicrobial resistance of hemophilies influ enzae. Methods Hemophilies influenzae was identified with satellite test. K-B method was applied for the drug susceptibility test,and nitrocefin test was used to detect β-lactamase. Results A total of 154 strains of hemophilies influ- enzae were mainly distributed in infection department （40 strains）,department of neurology and respiratory diseases （32 strains） and department of traditional Chinese medicine （30 strains）. The resistant rates to ampicil!in,ciprofloxa- cin,azithromycin and compound sulfamethoxazole were all above 60.00%, the resistant rates to meropenem and aztreonam were 0.00% and 8.44% respectively. The positive rate of β-lactamase was 20.13 %. Conclusion Hemophilies influenzae has high resistant rate and the drug resistance displays multiple. It suggests that antibacterials should be chosen according to antimicrobial susceptibility test results.