Evasion of cytotoxic T lymphocytes by murine cytomegalovirus |
| |
Authors: | Kavanagh D G Hill A B |
| |
Affiliation: | Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201-3098, USA. |
| |
Abstract: | Murine cytomegalovirus causes lifelong infections with little pathology in normal host animals. Control of viral replication and prevention of pathology depend on both innate and adaptive immune mechanisms, and cytolytic T lymphocytes play a key role in this process. The virus encodes a number of genes which alter the normal assembly of class I major histocompatability complex proteins, and thus interfere with the ability of infected cells to present antigen to CD8(+)T cells. This review will examine what is known about these viral genes, and present some unanswered questions regarding the role of CTL evasion in the viral infectious cycle. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|