埃索美拉唑三联疗法根除幽门螺杆菌感染61例疗效观察

目的研究埃索美拉唑三联疗法治疗消化性溃疡合并幽门螺杆菌(Hp)感染患者的疗效。方法121例患者均经胃镜及~(14)C尿素呼吸试验(UBT)检查,明确诊断后随机分为治疗组61例和对照组60例,治疗组应用埃索美拉唑片20 mg+阿莫西林1.0g+克林霉素0.5 g口服,每天2次,治疗2周;对照组给予法莫替丁20 mg+阿莫西林1.0 g+克林霉素0.5 g口服,每天2次,治疗2周。疗程结束后3 d观察Hp根除率、症状缓解率、溃疡愈合率。结果治疗组和对照组的症状缓解率分别为97.0%和81.0%,溃疡愈合率分别为96.0%和79.0%,Hp感染根除率分别为93.1%和74.0%,2组比较差异均有统计学意义(P<0.05)。结论埃索美拉唑三联疗法治疗Hp感染疗效确切、不良反应轻,是良好的根除消化性溃疡Hp的方法之一。

The effects of esomeprazole triple therapy for treatment of helicobacter pylori infection: 61 cases report

Objective To investigate the effect of esomeprazole triple therapy for treatment of peptic ulcer combined with heicobecter pylori（Hp） infection.Methods 121 patients diagnosed peptic ulcer combined with Hp infection by gastroendoscopy and ~（14）C urea breath testing（UBT） were randomly allocated to therapeutic group（61 cases） and control group（60 cases）.The therapeutic group were administered esomeprazole（20 mg,twice a day）, amoxicillin（1.0 g,twice a day） and clindamycin（0.5 g,twice a day） for 2 weeks.The control group were administered famotidine（20 mg,twice a day）,amoxicillin（1.0 g,twice a day） and clindamycin（0.5 g,twice a day） for 2 weeks.Three days after therapeutic period,the Hp eradication rate,symptoms and peptic ulcer healing rate were observed. Results The symptom ameliorate rate,peptic ulcer healing rate of the therapeutic group and control group were 97.0%and 81.0%,96.0%and 79.0%,respectively.The Hp eradication rate of the therapeutic group and control group were 93.1%and 74.0%,respectively.There are significant differences between the two groups（P0.05）.Conclusion The effect of esomeprazole triple therapy for Hp infection is definite,and side effects are less common.It is alternative option for Hp eradication.