2型糖尿病伴牙周炎患者血清RANKL和骨保护素水平的检测及意义 |
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引用本文: | 曹玉林,尚姝环,江汉,李成章.2型糖尿病伴牙周炎患者血清RANKL和骨保护素水平的检测及意义[J].武汉大学学报(医学版),2012,33(6):770-774. |
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作者姓名: | 曹玉林 尚姝环 江汉 李成章 |
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作者单位: | 1. 口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室/武汉大学口腔医学院 湖北 武汉 430079;益阳医学高等专科学校口腔中心 湖南益阳 413000 2. 口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室/武汉大学口腔医学院 湖北 武汉 430079;武汉大学口腔医学院牙周科 湖北武汉430079 3. 口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室/武汉大学口腔医学院 湖北 武汉 430079;武汉大学口腔医学院预防科 湖北武汉430079 |
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基金项目: | "十一五"国家科技支撑项目(项目编号:2007BAI18B02) |
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摘 要: | 目的:探讨慢性牙周炎伴2型糖尿病患者血清RANKL和骨保护素(OPG)浓度变化与牙槽骨破坏的关系.方法:检查和分析健康组、牙周炎组、2型糖尿病组以及2型糖尿病佯牙周炎组患者血清RANKL和OPG的浓度、空腹血糖水平及牙周检查指数.结果:与健康组相比,牙周炎组OPG显著降低,RANKL略增高,RANKL/OPG比值增高(P<0.05);糖尿病组OPG明显增高,RANKL几无变化,RANKL/OPG比值降低(P<0.05);糖尿病伴牙周炎组OPG明显增高,RANKL略增高,RANKL/OPG比值降低;与牙周炎组相比,糖尿病组和糖尿病伴牙周炎组OPG明显增高,RANKL/OPG比值降低(P<0.05);空腹血糖与临床附着丧失,OPG浓度呈正相关,与RANKL/OPG比值呈负相关(P<0.05).结论:糖尿病和牙周炎引起RANKL/OPG比值呈现不同的变化,提示糖尿病与牙周炎骨破坏机制可能不同,糖尿病患者与牙周病患者OPG浓度变化提示糖尿病患者的骨吸收可能还有未知的破骨机制.
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关 键 词: | 糖尿病 牙周炎 RANKL 骨保护素 |
Changes of Serum RANKL and Osteoprotegerin Levels and Their Significance in Diabetes Mellitus with Periodontitis |
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Abstract: | Objective: To measure the serum levels of RANKL and osteoprotegerin(OPG) in patients of diabetes mellitus with or without periodontitis,and to explore the relationship between alveolar bone destruction and RANKL/OPG concentration.Methods: The levels of serum RANKL and OPG were compared among health(H),periodontitis(P),diabetes mellitus(DM) and DM+P groups including blood test and periodontal examination.Results: In periodontitis group,OPG was significantly lower,RANKL was slightly increased,RANKL/OPG ratio was higher(P<0.05);in diabetes group,OPG was significantly higher(P<0.05),RANKL had almost no change,and RANKL/OPG ratio was decreased(P<0.05);in diabetes with periodontitis group,both RANKL and OPG were increased(P<0.05),but the ratio was reduced(P<0.05).In diabetes group and diabetes with periodontitis group,OPG was significantly higher(P<0.05),RANKL/OPG ratio was decreased compared to periodontitis group(P<0.05);fasting blood glucose was positively correlated to attachment loss and OPG levels(P<0.05),and negatively correlated to RANKL/OPG ratio.Conclusion: The cause of diabetes and periodontitis in the change of RANKL/OPG ratio was different;the changes of RANKL and OPG concentrations in diabetes and periodontal patients suggest unknown bone resorption mechanism. |
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Keywords: | Diabetes Mellitus Periodontitis RANKL Osteoprotegerin |
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