长期低剂量地红霉素在慢性鼻窦炎鼻息肉术后的应用

目的:观察地红霉素在慢性鼻窦炎鼻息肉术后应用的疗效.方法:63例慢性鼻窦炎鼻息肉患者术后随机分为两组,分别给于长期低剂量地红霉素(治疗组)及克拉霉素(对照组)治疗,同时给予生理盐水洗鼻和丙酸氟替卡松喷鼻剂喷鼻,采用海口标准评价手术疗效和视觉模拟量表评分法(VAS)评估主观症状.结果:1 2周后地红霉素组和克拉霉素组治疗有效率为87.9％和90％,两者差异无统计学意义(P＞0.05).两组患者治疗前后主观症状均有明显改善,治疗组在鼻塞、鼻漏症状评分(VAS)较对照组差异有显著性(P＜0.05).结论:口服地红霉素或克拉霉素有助于改善慢性鼻窦炎鼻息肉患者术后临床症状及治疗有效率,长期小剂量服用未发现严重的副作用,地红霉素有一定优势.

Long-Term and Low Dose Administration of Dirithromycin in Post-Operative Treatment of Rhinosinusitis with Nasal Polyps

Objective: To observe the efficacy of dirithromycin long-term and low dose using in post-operative treatment of rhinosinusitis with nasal polyps.Methods: Sixty-three patients with chronic rhinosinusitis and nasal polyps were randomly divided into dirithromycin group and clarithromycin group(as control group),combining with saline nasal washing and nasal fluticasone spray.The surgery efficacy and visual analog scale(VAS) score was compared between the two groups.Results: After 12 weeks,the effective rates of dirithromycin and clarithromycin groups were 87.9% and 90%,respectively,and the difference was not statistically significant(P>0.05).Significant improvements were found in both groups,but the dirithromycin group showed better improvement of nasal congestion and rhinorrhea symptoms than control group(P<0.05).Conclusion: The dirithromycin or clarithromycin was useful to improve the clinical symptoms of post-operation patients with chronic rhinosinusitis with nasal polyps.Also the way of long-term and low-dose using showed no serious side effects but dirithromycin showed more advantages.