颅脑创伤后颅内感染的危险因素分析

目的：探讨颅脑创伤（ TBI）后颅内感染的发生情况和危险因素，从而提高临床预见性和治疗效果。方法回顾性分析我科2011年1月～2013年12月收治的520例颅脑创伤患者的临床资料，其中男性308例，女性212例；年龄14～85岁，平均（40.22±8.46）岁。分析颅内感染的相关危险因素。结果32例（6.15％）出现颅内感染。颅内感染好发于损伤后4～10d。单因素分析显示脑脊液漏、外引流、多次开颅手术（≥2次）与颅内感染的发生密切相关； Logistic回归分析提示脑脊液漏（P＝0.0091，OR＝2.071）、外引流（P＝0.0165，OR＝1.923）为其独立危险因素。结论颅内感染是颅脑创伤的严重并发症之一，脑脊液漏或外引流患者更易出现颅内感染，临床上应予以足够重视，争取患者获得最佳的治疗效果。

Analysis on the risk factors related to intracranial infection secondary to traumatic brain injury

Objective To discuss the occurrence of intracranial infection after traumatic brain injury and its related risk factors for the improvement of the predictability and clinical treatment .Methods Data of 520 pa-tients with traumatic brain injury who were admitted into our department from Jan .2011 to Dec.2013 were retrospec-tively analyzed.There were 308 males and 212 females,with mean age of （40.22 ±8.46）years. The related risk factors of intracranial infection were analyzed .Results Intracranial infection occurred in 32 cases （6.15%）.In-tracranial infection usually occurred at 4 to 10 days after injury .Single factor analysis showed that cerebrospinal flu-id leakage,drainage,repeated craniotomy （≥2 times） were significantly related to the occurrence of intracranial in-fection .Logistic regression analysis indicated cerebrospinal fluid leakage and drainage as the independent factors for intracranial infection .Conclusion Intracranial infection is a serious complication of traumatic brain injury .Pa-tients with drainage or cerebrospinal fluid leakage are more prone to intracranial infection ,to which more attention should be taken so as to obtain a better prognosis .