首页 | 本学科首页   官方微博 | 高级检索  
     

二期梅毒患者外周血淋巴细胞凋亡及其免疫表型的研究
引用本文:曾文军,樊翌明,吴志华. 二期梅毒患者外周血淋巴细胞凋亡及其免疫表型的研究[J]. 中国麻风皮肤病杂志, 2005, 21(11): 844-846
作者姓名:曾文军  樊翌明  吴志华
作者单位:1. 广东省东莞市常平人民医院,东莞,523573
2. 广东医学院附属医院皮肤科,湛江,524001
基金项目:广东医学院立项资助课题(A2001512)
摘    要:目的:观察二期梅毒患者外周血淋巴细胞(PBLC)凋亡及其免疫表型,探讨二期梅毒患者免疫功能异常与淋巴细胞凋亡的关系。方法:采用流式细胞仪检测33例二期梅毒患者和30例正常人PBLC免疫表型与细胞凋亡。结果:梅毒患者外周血111细胞及Tn/Ts比值明显低于对照组(P〈0.01),而Ts细胞则显著高于对照组(P〈0.01)。B淋巴细胞两组问的差异无显著性(P〉0.05)。梅毒患者PBLC及CD4^+细胞凋亡率显著高于对照组(P〈0.01),CD8^+及CD19^+细胞凋亡率两组比较差异无显著性(P〉0.05);梅毒患者PBLC凋亡率与CD4^+细胞及CD4^+/CD8^+比值呈显著负相关(r=-0.675,P〈0.01;r=-0.782,P〈0.01),CD4^+细胞凋亡率与CD4^+细胞数呈显著负相关(r=-0.813,P〈0.01)。结论:二期梅毒患者存在细胞免疫功能抑制,其细胞免疫功能异常可能与淋巴细胞凋亡过度有关。

关 键 词:梅毒 淋巴细胞免疫表型 流式细胞仪 细胞凋亡 外周血淋巴细胞凋亡 梅毒患者 免疫表型 CD4^+/CD8^+比值 CD4^+细胞数 细胞凋亡率
收稿时间:2004-11-16
修稿时间:2004-11-16

Apoptosis and immunophenotype of peripheral blood lymphocytes in secondary syphilis
Zeng Wenjun,Fan Yiming,Wu Zhihua. Apoptosis and immunophenotype of peripheral blood lymphocytes in secondary syphilis[J]. China Journal of Leprosy and Skin Diseases, 2005, 21(11): 844-846
Authors:Zeng Wenjun  Fan Yiming  Wu Zhihua
Affiliation:Department of Dermatology, the Affiliated Hospital of Guangdong Medical College, Zhanfiang, 524001
Abstract:Objective: To investigate the correlation of apoptosis with immunophenotypes of peripheral blood lymphocyte (PBLC) in secondary syphilis. Methods: PBLC immunophenotype and apoptosis in 33 cases of secondary syphilis and 30 normal controls were determined by flow cytometry (FCM). Results: Compared with controls, Th cells and the ratio of Th/Ts were significantly decreased(P<0.01), whereas Ts cells were remarkably increased in syphilitics(P<0.01). There was no significant difference in B lymphocytes between both groups(P>0.05). Apoptosis of PBLCs and CD4~+ cells in syphilitics was superior to those in controls (P<0.01). Apoptosis of CD8~+ and CD19~+ cells in syphilitics was not different from those in controls (P>0.05). There was a negative correlation of PBLC apoptosis with CD4~+ cells and the ratio of CD4~+/CD8~+ (r=-0.675,P<0.01;r=-0.782,P<0.01) in syphilitic patients, and so was between CD4~+ cell apoptosis and CD4~+ cells(r=-0.813,P<0.01).Conclusion: There is a prominent suppression of celllar immunity in patients with secondary syphilis, which is associated with the excessive apoptosis of PBLCs.
Keywords:syphilis   lymphocyte immunophenotypes   flow cytometry   apoptosis
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号