核黄素对急性心肌梗塞兔心电图的影响

作者采用心前和心外膜标测技术。观察核黄素对急性心肌梗塞兔心电图的影响.实验动物随机分为生理盐水(NS)组和核黄素(VB_2)组。分析给药后5～120min 心电图的改变,结果发现:①VB_2组 ST 段抬高程度较 NS 组轻,给药后30min 两组差异显著(P<0.05);②VB_2组边缘区 ST段和 R 波幅度恢复明显,提示核黄素具有挽救边缘区频危心肌的作用;③核黄素能抑制 Q 波的发生和发展,并使心率减慢.上述结果从电生理角度证明核黄素具有改善心肌缺血的作用。

THE EFFECT OF RIBOFLAVIN ON ELECTRO CARDIOGRAM IN RABBITS WITH EXPERIMENTAL MYOCARDIAL INFARCTION

Effects of riboflavin on electrocardiogram(ECG)in rabbits with acute myocardial intarction(AMI)were observed by precardial and epicardial techniques.Rabbits were randomly divided into two groups:saline(NS)and riboflavin(VB_2).The change of ECG were analysed from 5 to 120 min after intravenous riboflavin infusion(100mg).The results showed that:(1)The degree of ST-segment elevation in VB_2 group was less than that in NS group.The difference between the two groups was significant 30 min after infusion(P<0.05).(2)The ST-segment elevation and amplitude reduction of R wave were soon restored to normal in border of ischemic zone in VB_2 group.(3)Q wave development was dcrpressed by riboflavin.(4)The administration of riboflavin decrease heart rate significantly(P<0.05).Thus the effect of riboflavin on improvement of ischemic myocardium is further confirmed with electrophysiology.