| 曲马朵急性戒断反应诱导小鼠大脑皮层μ受体mRNA表达增加 |
| |
| 引用本文： | 孙红蕾,梁建辉,王铿,郑继旺. 曲马朵急性戒断反应诱导小鼠大脑皮层μ受体mRNA表达增加[J]. 中国药物依赖性杂志, 2003, 12(4): 258-261 |
| |
| 作者姓名： | 孙红蕾 梁建辉 王铿 郑继旺 |
| |
| 作者单位： | 北京大学中国药物依赖性研究所,北京,100083 |
| |
| 摘 要： | 目的 :从分子水平探讨曲马朵急性戒断机理及 5 -羟色胺酸、育亨宾对曲马朵急性戒断反应的影响。方法 :利用RT -PCR技术研究小鼠大脑皮层 μ受体mRNA表达的变化。 结果 :曲马朵急性戒断小鼠 μ受体mRNA的表达明显升高 ,增加了 15 3.3% ,而育亨宾和 5 -HTP可抑制曲马朵急性戒断诱导的 μ受体mRNA改变。 结论 :中枢 5 -羟色胺系统和去甲肾上腺素系统对曲马朵急性戒断诱导的小鼠大脑皮层 μ受体mRNA高表达具有调节作用
|
| 关 键 词： | 曲马朵 阿片戒断 5-羟色胺酸 育亨宾 阿片受体 |
| 修稿时间： | 2003-03-14 |
ACUTE TRAMADOL ABSTINENCE ENHANCES THE EXPRESSION OF MU RECEPTOR mRNA IN CEREBRAL CORTEX OF MICE |
| |
| SUN Honglei,LIANG Jianhui ,WANG Keng,ZHENG Jiwang. ACUTE TRAMADOL ABSTINENCE ENHANCES THE EXPRESSION OF MU RECEPTOR mRNA IN CEREBRAL CORTEX OF MICE[J]. Chinese Journal of Drug Dependence, 2003, 12(4): 258-261 |
| |
| Authors: | SUN Honglei LIANG Jianhui WANG Keng ZHENG Jiwang |
| |
| Affiliation: | SUN Honglei,LIANG Jianhui *,WANG Keng,ZHENG Jiwang |
| |
| Abstract: | Objective: To study the possible molecular mechanisms underlying acute tramadol abstinence and the effect of 5-hydroxyptrytophan and yohimbine upon acute tramadol withdrawal. Methods: The expression of μ receptor mRNA in cerebral cortex of mice was investigated by RT-PCR. Results: In acute tramadol abstinence mice, the expression of μ receptor mRNA was 153.3% higher than that of control mice, while yohimbine and 5-hydroxyptrytophan inhibited the up-regulation of μ receptor gene expression induced by acute tramadol abstinence. Conclusion: The serotonergic and adrenergic systems in the CNS could regulate the high expression of μ receptor mRNA induced by acute tramadol abstinence in cerebral cortex of mice. |
| |
| Keywords: | tramadol opioid abstinence 5-hydroxyptrytophan yohimbine opioid receptor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
