The effects of knee osteoarthritis on neural activity during a motor task: A scoping systematic review |
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| Affiliation: | 1. School of Health & Rehabilitation Sciences, The Ohio State University, 453 W. 10th Avenue, Columbus, OH 43210, USA;2. Ohio State Sports Medicine, The Ohio State University Wexner Medical Center, 2835 Fred Taylor Dr., Columbus, OH 43202, USA;3. Sports Medicine Research Institute, The Ohio State University Wexner Medical Center, 2835 Fred Taylor Dr., Columbus, OH 43202, USA;4. Department of Orthopaedics, The Ohio State University Wexner Medical Center, 2835 Fred Taylor Dr., Columbus, OH 43202, USA;5. Division of Physical Therapy, School of Rehabilitation and Communication Sciences, College of Health Sciences and Professions, Ohio University, Athens, OH 45701, USA;6. Division of Athletic Training, School of Applied Health Sciences and Wellness, College of Health Sciences and Professions, Ohio University, Athens, OH 45701, USA;7. Ohio Musculoskeletal and Neurological Institute, Ohio University, Athens, OH 45701, USA;1. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy;2. Dipartimento di Meccanica, Politecnico di Milano, Milano, Italy;3. Exercise Physiology and Physical Assessment Laboratory, Serra Gaúcha University Center, Caxias do Sul, Brazil;4. Integrated Colleges of Taquara (FACCAT), Taquara, Brazil;1. Center for Motion Analysis, Connecticut Children’s Medical Center, Farmington, CT, USA;2. Children’s Orthopaedic Center, Children’s Hospital Los Angeles, Los Angeles, CA, USA;1. Ziauddin University, 128/2 14th Street off Khayaban e Muhafiz Phase 6 Defence Housing Authority Karachi, Pakistan;2. Shaheed Mohtarma Benazir Bhutto Medical College Liyari, Parsa citi, Garden East, Karachi, Pakistan;3. Dow University of Health Sciences, Bridge View Apartment, Frere Town, Clifton Block 8, Karachi 75600, Pakistan;1. Laboratory of Biological Evaluation of Human Performance, Department of Physical Education and Sport Science at Thessaloniki, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;2. Faculty of Health Sciences, Metropolitan College of Thessaloniki, 14 El. Venizelou Str., 54624 Thessaloniki, Greece;3. Biomechanics Laboratory, Department of Physical Education and Sport Science at Thessaloniki, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;4. School of Physical Education and Sport Science at Serres, Aristotle University of Thessaloniki, 62110 Ag. Ioannis Serres, Greece;1. Gillette Children’s Specialty Healthcare, St. Paul, MN, United States;2. Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, United States |
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| Abstract: | ObjectiveTo examine the evidence of neural activation with functional magnetic resonance imaging (fMRI), corticospinal excitability, and other central nervous system measurement differences during motor tasks between those with and without knee osteoarthritis (KOA).MethodsA scoping review strategy was systematically performed. We searched PubMed, CINAHL, Embase, PsychInfo, SportDiscus, SCOPUS and Web of Science from database inception to April 2021. Any study investigating central nervous system measures during a motor task for individuals with KOA with or without a healthy control group for comparison was included. Two reviewers independently screened all studies in accordance with the Preferred Reported Items for Systematic Reviews and Meta-analyses extension for scoping reviews.ResultsThirteen studies met the inclusion criteria. KOA had reduced activation of the premotor cortex during a gait imagery task when examining the brain using fMRI. This hypoactivation was not significant when the task was combined with ankle movement. Individuals with KOA had decreased motor cortex activation during a force matching motor task. KOA was associated with gamma loop dysfunction of the quadriceps and increased responsiveness of the triceps surae muscles. Also, there was an increased soleus Hoffmann reflex during heel strike of gait cycle. The flexor withdrawal reflex was heighted for individuals with KOA with a lower threshold of the reflex occurring with increased joint compression, but this reflex was modulated with joint mobilizations.ConclusionIndividuals with KOA have motor deficits associated with decreased neural activation, central nervous system sensitization, decreased quadriceps muscle spindle responsiveness, and increased triceps surae muscle activity. |
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| Keywords: | Functional magnetic resonance imaging Transcranial magnetic stimulation Hoffmann’s Reflex |
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